Recent Advances in the Synthesis and Applications of m-Aryloxy Phenols

Abstract

Since phenol derivatives have high potential as building blocks for the synthesis of bioactive natural products and conducting polymers, many synthesis methods have been invented. In recent years, innovative synthetic methods have been developed for the preparation of m-aryloxy phenols, which has allowed for the preparation of complex m-aryloxy phenols with functional groups, such as esters, nitriles, and halogens, that impart specific properties of these compounds. This review provides an overview of recent advances in synthetic strategies for m-aryloxy phenols and their potential biological activities. This paper highlights the importance of m-aryloxy phenols in various industries, including plastics, adhesives, and coatings, and it discusses their applications as antioxidants, ultraviolet absorbers, and flame retardants.

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

“…The resorcinol group is typically found in the A-ring and is characterized by the two hydroxyl groups in the meta position [ 191 ] ( Figure 13 ). Resorcinol and catechol are nucleophilic intermediates used in synthesis [ 192 ].…”

“…The resorcinol group is typically found in the A-ring and is characterized by the two hydroxyl groups in the meta position [191] (Figure 13). Resorcinol and catechol are nucleophilic intermediates used in synthesis [192]. Phenols and polyphenols are nucleophiles due to the high electron density on the oxygen atom of the hydroxyl group and this makes them susceptible to electrophilic substitution reactions [193,194].…”

“…The resorcinol group is typically found in the A-ring and is characterized by the two hydroxyl groups in the meta position [191] (Figure 13). Resorcinol and catechol are nucleophilic intermediates used in synthesis [192]. As antioxidants, polyphenols can counteract free radicals and reactive species, i.e., unstable chemicals that can damage various molecules in cells, such as proteins [140].…”