Recent advances in the study of ancient books on traditional chinese medicine

Gao, Li; Chun-hua, Jia; Wang, Wei

doi:10.4103/wjtcm.wjtcm_3_20

Cited by 19 publications

(15 citation statements)

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“… 132 Furthermore, Allen et al efficaciously reconnoitred the degradation of pristine and oxidized SWCNTs with the help of oxidative enzyme horseradish peroxidase (HRP) as a catalytic agent. 133 Lippard et al described earlier that Pt (IV) prodrug conjugated with soluble SWCNTs revealed successful delivery of CDDP using toxic dose on selective intracellular reduction. 133 The same research group developed SWCNT-Pt (IV) complex with targeting molecules, containing a folate derivative (FA) at an axial position.…”

Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

“… 133 Lippard et al described earlier that Pt (IV) prodrug conjugated with soluble SWCNTs revealed successful delivery of CDDP using toxic dose on selective intracellular reduction. 133 The same research group developed SWCNT-Pt (IV) complex with targeting molecules, containing a folate derivative (FA) at an axial position. The authors demonstrated the SWCNT–Pt (IV)-FA efficacy over human cells, including choriocarcinoma and human nasopharyngeal carcinoma cells.…”

Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

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Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Edis¹,

Wang²,

Waqas³

et al. 2021

IJN

188

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Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.

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Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Edis¹,

Wang²,

Waqas³

et al. 2021

IJN

188

View full text Add to dashboard Cite

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“…A large number of TCM works and studies, 25 , 26 such as the Code of Practice for Chinese Medicine , state that DU20 and DU24 are the two most frequently used acupoints for the treatment of cognitive-related symptoms. These are two important acupoints of the Du meridian and fulfill the functions of dredging that meridian, regulating and refreshing the mind, inducing resuscitation, and calming the spirit.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Electroacupuncture Preconditioning on Regional Cerebral Oxygen Saturation Levels in Elderly Patients with Diabetes

Ning¹,

Luo²,

Ding³

et al. 2022

DMSO

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Objective This study aimed to evaluate the effect of electroacupuncture preconditioning on regional cerebral oxygen saturation (rSO 2 ) levels in elderly patients with diabetes. Methods Forty patients undergoing elective diabetic foot surgery were enrolled in this study. All patients were aged 65 years and above and weighed 45–75 kg. All were characterized as class II or III according to the American Society of Anesthesiologists’ physical status classification system. Patients were divided randomly into an electroacupuncture group (group E) and a control group (group C); both groups comprised 20 patients. In group E, the DU20 (Baihui), DU24 (Shenting), and EX-HN1 (Sishencong) acupoints were selected for electroacupuncture 30 min prior to administering anesthesia, while in group C, patients underwent routine anesthesia without electroacupuncture. The patients in both groups were anesthetized using a sciatic nerve block. The number of cases with increased or decreased regional oxygen saturation (rSO 2 ) compared with the baseline as well as rSO 2 variability in the two groups were recorded and compared. Results There was no significant difference in the preoperative rSO 2 values between the two groups (54.4 ± 4.8 (L), 53.9 ± 5.2 (R) [group C] vs 54.1 ± 5.2 (L), 54.5 ± 4.6 (R)[group E]). Compared with group C, the rSO 2 in group E increased (50.3 ± 3.9 [group C] vs 58.4 ± 3.2[group E]), and this difference was statistically significant (P < 0.001). Conclusion Electroacupuncture stimulation can increase rSO 2 levels in patients with diabetes. Clinical Registration Number ChiCTR2100048783 ( http://www.chictr.org.cn ).

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“…Amongst the three, the ERK pathway has been touted as a stimulant for the expression and regulation of growth factors like VEGF, leading to osteogenic differentiation. A study shed light on the possible mechanism of the ERK pathway, which described the signaling pathway to be activated by HMGB1, for the induction and migration of fibroblasts to accentuate wound healing [ 48 , 49 ]. The reported literature has elucidated the function of ABR to be effective in mitigating bone trauma and injury through modulating different immune responses that treat and reduce damage to the bone tissue.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma

Hao

Dai

et al. 2021

BioMed Research International

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Purpose. Bone trauma is a clinical condition that afflicts the majority of the world’s population. For the management of bone trauma, the underlying mechanisms of the drugs effective for bone healing are deemed necessary. Achyranthis bidentatae Radix (ABR) is a popular alternative medicine recommended in the treatment of bone trauma and injury, yet its mechanism of action persists to be vague. This study was conducted for the evaluation of the mode of action of ABR through network pharmacology in treating bone trauma. Methods. An extensive survey of published works led to the development of a drug-target database, after which multiple protein targets for bone trauma were discerned. The protein-protein interaction network was developed by utilizing the STITCH database and gene ontology (GO) enrichment analysis using Cytoscape and ClueGO. Moreover, docking studies were performed for revealing the affinity of various ingredients with IL6. Results. The extensive literature survey yielded the presence of 176 components in ABR, and 151 potential targets were acquired. Scrutinization of these targets revealed that 21 potential targets were found to be associated with bone trauma. Out of which, some remarkable targets such as IL6, MAPK14, MAPK8, SRC, PTGS2, and MMP2 were observed to be associated in the functional interaction of ABR. According to docking results, several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have the lowest docking scores (range between -6 and -7). Conclusions. The results of the study elucidated that ABR can positively be utilized for the management of bone trauma, which can be mediated by multiple molecular mechanisms such as ERBB2 signaling pathway, positive regulation of oxidoreductase activity, JNK cascade pathway, multicellular organism metabolic process, T cell costimulation, and the positive regulation of MAPK activity. The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6.

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Recent advances in the study of ancient books on traditional chinese medicine

Cited by 19 publications

References 1 publication

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

The Effect of Electroacupuncture Preconditioning on Regional Cerebral Oxygen Saturation Levels in Elderly Patients with Diabetes

Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma

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