Recent advances in the rational synthesis and sensing applications of metal-organic framework biocomposites

Qiu, Qi–Ming; Chen, Huayun; Wang, Yixian; Ying, Yibin

doi:10.1016/j.ccr.2019.02.009

Cited by 190 publications

(88 citation statements)

References 138 publications

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“…Many biomacromolecules@ZIF-8, including enzymes@-ZIF-8, were recently developed as robust platform for biocatalysis,b iosensing, biobanking and bioprocessing. [10,11,56,57] Furthermore,i ncreasing efforts were devoted to construct biomacromolecule@nanoZIF-8 intracellular delivery systems for protein-and gene-based theranostics. [25,[58][59][60] These applications receive more and more attention because of the high loading efficiency and protecting effect of ZIF-8, and the convenient de novo synthesis process.H erein, we highlighted the importance of the embedding patterns for facilitating and preserving the biofunctionality of abiomacromolecule encapsulated within ZIF-8.…”

Section: Resultsmentioning

confidence: 99%

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

et al. 2020

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Embedding an enzyme within aMOF as exoskeleton (enzyme@MOF) offers new opportunities to improve the inherent fragile nature of the enzyme,but also to impart novel biofunctionality to the MOF.D espite the remarkable stability achieved for MOF-embedded enzymes,e mbedding patterns and conversion of the enzymatic biofunctionality after entrapment by aM OF have only received limited attention. Herein, we reveal howe mbedding patterns affect the bioactivity of an enzyme encapsulated in ZIF-8. The enzyme@MOF can maintain high activity when the encapsulation process is driven by rapid enzyme-triggered nucleation of ZIF-8. When the encapsulation is driven by slow coprecipitation and the enzymes are not involved in the nucleation of ZIF-8, enzy-me@MOF tends to be inactive owing to unfolding and competing coordination caused by the ligand, 2-methyl imidazole.T hese two embedding patterns can easily be controlled by chemical modification of the amino acids of the enzymes,modulating their biofunctionality.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Section: Resultsmentioning

confidence: 99%

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

et al. 2020

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“…Many biomacromolecules@ZIF‐8, including enzymes@ZIF‐8, were recently developed as robust platform for biocatalysis, biosensing, biobanking and bioprocessing . Furthermore, increasing efforts were devoted to construct biomacromolecule@nanoZIF‐8 intracellular delivery systems for protein‐ and gene‐based theranostics .…”

Section: Resultsmentioning

confidence: 99%

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

et al. 2020

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Embedding an enzyme within a MOF as exoskeleton (enzyme@MOF) offers new opportunities to improve the inherent fragile nature of the enzyme, but also to impart novel biofunctionality to the MOF. Despite the remarkable stability achieved for MOF‐embedded enzymes, embedding patterns and conversion of the enzymatic biofunctionality after entrapment by a MOF have only received limited attention. Herein, we reveal how embedding patterns affect the bioactivity of an enzyme encapsulated in ZIF‐8. The enzyme@MOF can maintain high activity when the encapsulation process is driven by rapid enzyme‐triggered nucleation of ZIF‐8. When the encapsulation is driven by slow coprecipitation and the enzymes are not involved in the nucleation of ZIF‐8, enzyme@MOF tends to be inactive owing to unfolding and competing coordination caused by the ligand, 2‐methyl imidazole. These two embedding patterns can easily be controlled by chemical modification of the amino acids of the enzymes, modulating their biofunctionality.

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“…Metal–organic frameworks (MOFs), a kind of crystalline porous materials constructed by connecting metal ions/clusters and bridging organic ligands via coordination bonds, have been extensively studied for applications in catalysis, gas storage and separation, drug delivery, and sensing owing to their tailorable structure and function, ultrahigh porosity and large surface area. Although many promising methods have been applied to prepare multifunctional MOFs, such as modulating crystal structure and compounding with other functional materials, their performance still needs great improvement.…”

Section: Introductionmentioning

confidence: 99%

Controllable Synthesis of Porphyrin‐Based 2D Lanthanide Metal–Organic Frameworks with Thickness‐ and Metal‐Node‐Dependent Photocatalytic Performance

et al. 2020

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Synthesizing 2D metal–organic frameworks (2D MOFs) in high yields and rational tailoring of the properties in a predictable manner for specific applications is extremely challenging. Now, a series of porphyrin‐based 2D lanthanide MOFs (Ln‐TCPP, Ln=Ce, Sm, Eu, Tb, Yb, TCPP=tetrakis(4‐carboxyphenyl) porphyrin) with different thickness were successfully prepared in a household microwave oven. The as‐prepared 2D Ln‐TCPP nanosheets showed thickness‐dependent photocatalytic performances towards photooxidation of 1,5‐dihydroxynaphthalene (1,5‐DHN) to synthesize juglone. Particularly, the Yb‐TCPP displayed outstanding photodynamic activity to generate O2− and 1O2. This work not only provides fundamental insights into structure designing and property tailoring of 2D MOFs nanosheets, but also pave a new way to improve the photocatalytic performance.

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Recent advances in the rational synthesis and sensing applications of metal-organic framework biocomposites

Cited by 190 publications

References 138 publications

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

Modulating the Biofunctionality of Metal–Organic‐Framework‐Encapsulated Enzymes through Controllable Embedding Patterns

Controllable Synthesis of Porphyrin‐Based 2D Lanthanide Metal–Organic Frameworks with Thickness‐ and Metal‐Node‐Dependent Photocatalytic Performance

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