Recent advances in the protective role of metallic nanoparticles in red blood cells

Yadav, Somu; Maurya, Pawan Kumar

doi:10.1007/s13205-021-03087-x

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…The hemolytic activity of both nanoparticles was similar with a very low hemolytic activity, indicating a higher safety when applied to patients. Previous research has indicated that red blood cells are very sensitive to oxidative activity [ 30 ]. When comparing the safety of ciprofloxacin loaded to silver and SiO-NPs, SiO-NPs have been found to be safer than AgNPs even at a higher dose of 500 μg/mL silver.…”

Section: Discussionmentioning

confidence: 99%

Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis

Jaber,

Saadh

2024

Vet World

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Background and Aim: Brucella melitensis is responsible for brucellosis, a highly contagious, life-threatening disease that has a high impact in low- and middle-income countries. This study aimed to compare silica nanoparticles (SiO-NPs) loaded with ciprofloxacin with silver nanoparticles (AgNPs) loaded with ciprofloxacin to evaluate the possible replacement of silver by silica to enhance biological activity and reduce cytotoxicity. Materials and Methods: SiO-NPs and AgNPs loaded with ciprofloxacin were characterized using ultraviolet spectroscopy, scanning electron microscopy, and dynamic light scattering microscopy for size demonstration and loading efficiency. Both nanoparticles were treated with B. melitensis Rev 1 to evaluate their biological activity. Nanoparticle toxicity was also evaluated using cytotoxicity and hemolysis assays. Results: SiO-NP was found to have a smaller size (80 nm) and higher loading efficiency with polydispersity index and zeta potential of 0.43 and 30.7 mV, respectively, compared to Ag-NP (180 nm and 0.62 and 28.3 mV, respectively). SiO-NP was potent with a minimum inhibitory concentration of 0.043 μg/mL compared to Ag-NP (0.049 μg/mL), with a lower cytotoxicity and hemolysis activity. Conclusion: SiO-NP, as a drug delivery system for ciprofloxacin, has better antimicrobial activity against B. melitensis with lower cytotoxicity and hemolysis activity. These results can be attributed to the enhanced physical characterization and better loading efficiency when compared to Ag-NP. Keywords: antimicrobial activity, brucellosis, minimum inhibitory concentration, nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis

Jaber,

Saadh

2024

Vet World

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Integrative investigation of hematotoxic effects induced by low doses of lead, cadmium, mercury and arsenic mixture: In vivo and in silico approach

Živančević,

Živanović,

Baralić

et al. 2024

Science of The Total Environment

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Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility

2022

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The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch of science, named nanotoxicology, which aims to study the dangerous effects of nanomaterials on human health and on the environment, has recently emerged. However, the toxicity and risk associated with nanomaterials are unclear or not completely understood. The development of an adequate experimental strategy for assessing the toxicity of nanomaterials may include a rapid/express method that will reliably, quickly, and cheaply make an initial assessment. One possibility is the characterization of the hemocompatibility of nanomaterials, which includes their hemolytic activity as a marker. In this review, we consider various factors affecting the hemolytic activity of nanomaterials and draw the reader’s attention to the fact that the formation of a protein corona around a nanoparticle can significantly change its interaction with the red cell. This leads us to suggest that the nanomaterial hemolytic activity in the buffer does not reflect the situation in the blood plasma. As a recommendation, we propose studying the hemocompatibility of nanomaterials under more physiologically relevant conditions, in the presence of plasma proteins in the medium and under mechanical stress.

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Recent advances in the protective role of metallic nanoparticles in red blood cells

Cited by 3 publications

References 70 publications

Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis

Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis

Integrative investigation of hematotoxic effects induced by low doses of lead, cadmium, mercury and arsenic mixture: In vivo and in silico approach

Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility

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