Recent advances in the production, properties and applications of alginate oligosaccharides - a mini review

Li, Li; Jiang, Jinju; Yao, Zhong; Zhu, Benwei

doi:10.1007/s11274-023-03658-5

Cited by 12 publications

(2 citation statements)

References 103 publications

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“…Therefore, degrading the polysaccharide molecule can be a solution in this case [60]. Sodium alginate has been approved to exert a variety of favorable biological functions such as anti-inflammatory effects [61]. Niu, et al in 2022 suggested that the use of sodium alginate accompanied by chlorogenic acid enhances therapeutic effect on ulcerative colitis by controlling inflammatory factors, oxidative stress, and the intestine microbita [62].…”

Section: Anti-inflammatory Effects Of Sodium Alginate and Its Molecul...mentioning

confidence: 99%

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

Mirshafiey

2024

BJSTR

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Owing to safety and unique properties, alginates are widely used in Biomedicine, food industry and pharmaceutics products. The multifaceted properties of alginate make it a captivating topic for extra scientific exploration in the anti-inflammatory and anti-tumoral areas. This paper describes the biological properties including anti-cancer and anti-inflammatory functions of sodium alginate and its components, mannuronic acid and guluronic acid, as alginate derivatives. However, the wide application of alginates as polysaccharides is limited due to their high molecular weight and low solubility; therefore, its degraded monomers, mannuronic acid and guluronic acid as products of alginate hydrolysate can be a solution in this case. In conclusion, these natural non-toxic, biocompatible, biodegradable, and quite cost-effective materials are totally operative for cancer management and control of inflammation, as their important biological effects and health benefits, in addition to their wide applications in food industry.

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Section: Anti-inflammatory Effects Of Sodium Alginate and Its Molecul...mentioning

confidence: 99%

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

Mirshafiey

2024

BJSTR

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“…Alginate is a copolymer with two different repeating units of mannuronic and guluronic acid, capable of forming a gel when placed in a solution containing a bivalent cation such as Ca 2+ [25,26]. Since the final application is likely to be something that requires the biocompatibility and biodegradability of the material, alginate was also selected because it possesses these properties and is widely used in a variety of applications ranging from drug delivery to the food industry [27][28][29]. As an example, Takatsuka et al [30] developed an alginate-based hydrogel microbead for gene delivery via adeno-associated viruses (AAV).…”

Section: Introductionmentioning

confidence: 99%

Biphasic Porous Bijel-Like Structures with Hydrogel Domains as Controlled Drug Delivery Systems

Pizzetti,

Massobrio,

Riva

et al. 2024

Gels

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Bijels are a peculiar type of Pickering emulsion that have a bicontinuous morphology and are stabilised by a jammed layer of nanoparticles (NPs). Due to their double nature, their usage has increased in recent years in various fields, such as biological and food applications. In fact, they can release both hydrophilic and hydrophobic compounds simultaneously. An improvement to this structure is the use of a hydrophobic monomer like polycaprolactone as the organic phase, which is able to polymerise during the formation of the structure. Unfortunately, the structures formed in this way always have some drawbacks, such as their thermal stability or degradation when submerged in an aqueous medium. A number of studies have been carried out in which some parameters, such as the NPs or the monomer, were changed and their effect on the final product evaluated. In this work, the effect of modifying the aqueous phase was studied. In particular, the effect of adding alginate, a biopolymer capable of forming a stable hydrogel in the presence of divalent cations, was analysed, as was the difference between soaking or not in CaCl2, the final system. Specific attention was paid to their swelling behaviour (150% vs. 25% of the blank sample), rheological properties (G′ 100 kPa vs. 20 kPa of the blank sample) and their release performances. In this framework, complete release of hydrophilic drug vs. 20% in the blank sample was observed together with improved release of the hydrophobic one with 35% in 8 h vs. 5% in the case of the blank sample. This strategy has been proven to influence bijels’ properties, opening the doors to many different uses

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