Recent Advances in the Prevention and Screening of Preeclampsia

Mészáros, Balázs; Kukor, Zoltán; Valent, Sándor

doi:10.3390/jcm12186020

Cited by 3 publications

(2 citation statements)

References 132 publications

(133 reference statements)

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“…It verified that a father who has “fathered” a pre-eclamptic pregnancy has a double risk of generating a pre-eclamptic pregnancy with another woman as well. This phenomenon has been referred to as “the dangerous father” [ 39 ]. The mammalian fetus, after the phase of implantation of the blastocyst, is intimately connected with the uterine tissues and the maternal blood system.…”

Section: The Father and Pre-eclampsiamentioning

confidence: 99%

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

Giannubilo,

Marzioni,

Tossetta

et al. 2024

Biology

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Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the fetal genetic heritage of paternal derivation can be decisive in cases of inherited chromosomal disorders, and can be the result of de novo genetic alterations. In addition to the strictly pathological aspects, paternal genetics may transmit thrombophilic traits that affect the implantation and vascular construction of the feto-placental unit, lead to placenta-mediated diseases such as pre-eclampsia and fetal growth retardation, and contribute to the multifactorial genesis of preterm delivery. Biological aspects of immunological tolerance to paternal antigens also appear to be crucial for these pathologies. Finally, this review describes the biological findings by which the environment, exposure to pathogens, lifestyle, and nutritional style of the father affect fetal pathophysiological and epigenetic definition.

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Section: The Father and Pre-eclampsiamentioning

confidence: 99%

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

Giannubilo,

Marzioni,

Tossetta

et al. 2024

Biology

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“…Despite its significant impact on obstetrics and healthcare in general, preeclampsia has remained an enigmatic field of medicine. However, recently, new preventive and screening methods have been tested ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?

Mészáros,

Veres,

Nagyistók

et al. 2024

Front. Med.

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ObjectiveMeta-analysis focusing on the role of first-trimester neutrophil-to-lymphocyte ratio (NLR) in the prediction of preeclampsia.Data sourcesPubMed, Scopus, Web of Science, Cochrane Library, and Embase databases were queried from inception up to December 31, 2022.Study eligibility criteriaThe study included all types of original research that was conducted in humans and values of NLR were measured during the first trimester, among patients who later developed preeclampsia, compared to the values of control groups.Study appraisal and synthesis methodsTwo reviewers independently performed data abstraction and quality appraisal, and disagreements were resolved by consensus and, if necessary, by the opinion of a third reviewer. During the analysis, PRISMA and MOOSE guidelines were followed. All statistical analyses were made with R.ResultsFor the research on the predictive role of NLR values in the first trimester for preeclampsia, a total of 6 studies were selected for analysis, covering 2,469 patients. The meta-analysis revealed a 95% confidence interval (CI) for the effect size of 0.641 to 1.523, with a prediction interval of 0.027 to 2.137.ConclusionBased on the analysis, NLR is a promising biochemical marker for future pieces of research that try to find new screening methods for first-trimester preeclampsia. We encourage other researchers to examine NLR’s predictive value combined with other markers in preeclampsia screening, this way being able to find new and affordable protocols for first-trimester preeclampsia screening.Systematic review registrationidentifier CRD42023392663.

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Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia

Gál,

Fóthi,

Orosz

et al. 2024

Front. Immunol.

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IntroductionPreeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset hypertension and proteinuria and it is often associated with fetal intrauterine growth restriction (IUGR). PE leads to long-term health complications, so early diagnosis would be crucial for timely prevention. There are multiple etiologies and subtypes of PE, and this heterogeneity has hindered accurate identification in the presymptomatic phase. Recent investigations have pointed to the potential role of small regulatory RNAs in PE, and these species, which travel in extracellular vesicles (EVs) in the circulation, have raised the possibility of non-invasive diagnostics. The aim of this study was to investigate the behavior of exosomal regulatory small RNAs in the most severe subtype of PE with IUGR.MethodsWe isolated exosomal EVs from first-trimester peripheral blood plasma samples of women who later developed preterm PE with IUGR (n=6) and gestational age-matched healthy controls (n=14). The small RNA content of EVs and their differential expression were determined by next-generation sequencing and further validated by quantitative real-time PCR. We also applied the rigorous exceRpt bioinformatics pipeline for small RNA identification, followed by target verification and Gene Ontology analysis.ResultsOverall, >2700 small RNAs were identified in all samples and, of interest, the majority belonged to the RNA interference (RNAi) pathways. Among the RNAi species, 16 differentially expressed microRNAs were up-regulated in PE, whereas up-regulated and down-regulated members were equally found among the six identified Piwi-associated RNAs. Gene ontology analysis of the predicted small RNA targets showed enrichment of genes in pathways related to immune processes involved in decidualization, placentation and embryonic development, indicating that dysregulation of the induced small RNAs is connected to the impairment of immune pathways in preeclampsia development. Finally, the subsequent validation experiments revealed that the hsa_piR_016658 piRNA is a promising biomarker candidate for preterm PE associated with IUGR.DiscussionOur rigorously designed study in a homogeneous group of patients unraveled small RNAs in circulating maternal exosomes that act on physiological pathways dysregulated in preterm PE with IUGR. Therefore, our small RNA hits are not only suitable biomarker candidates, but the revealed biological pathways may further inform us about the complex pathology of this severe PE subtype.

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Recent Advances in the Prevention and Screening of Preeclampsia

Cited by 3 publications

References 132 publications

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?

Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia

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