Recent advances in the preparation and use of molecularly imprinted polymers for enantiomeric resolution of amino acid derivatives

O’Shannessy, Daniel J.; Ekberg, Björn; Andersson, Lars I.; Mosbach, Klaus

doi:10.1016/s0021-9673(01)83567-6

Cited by 86 publications

(35 citation statements)

References 13 publications

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“…243,363,378,388,397,398,425,745,856,904,913,925,[999][1000][1001][1002][1003][1004][1005][1006][1007][1008][1009][1010][1011][1012] Partly on account of its UV-activity, the amino acid phenylalanine and its derivatives have proven to be most useful templates in fundamental studies on MIP chromatographic performance, in particular in work by Sellergren et al with phenylalanine anilide, 913,925,1012 which has been an important tool in many studies on aspects of non-covalent molecular imprinting in general.…”

Section: Amino Acids and Derivatives Peptides And Proteinsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.

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Section: Amino Acids and Derivatives Peptides And Proteinsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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“…20 For determination of the specific binding properties of MIP, imprinted and nonimprinted Nylon-6 stir bars were equilibrated with L-glutamine (100 lmol L 21 ) in water, methanol, acetonitrile and acetic acid/ methanol at 208C for 60 min. The change of L-glutamine concentrations in the solution was determined by reversed-phase HPLC.…”

Section: Resultsmentioning

confidence: 99%

Molecular imprinted Nylon‐6 stir bar as a novel extraction technique for enantioseparation of amino acids

Zhu

2008

J of Applied Polymer Sci

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ABSTRACT:The flexibility and simplicity of stir bar sorption extraction (SBSE) have been combined with the selectivity of molecularly imprinted polymers (MIP). Stir bars were coated reproducible with a 160-lm film formed from a formic acid solution of Nylon-6 polymer either nonimprinted or imprinted with L-glutamine. Time sorption profiles were measured for the extraction of L-glutamine at the concentration of 20-500 lmol L 21 levels with both types of films in order to compare sorption characteristics. The results indicated that the MIP coated layer showed remarkable high affinity towards L-glutamine and equilibrium adsorption was attained rapidly (60 min) in contrast to conventional bulk molecularly imprinted polymer in which equilibrium adsorption was normally attained after 16-24 h. The imprinted stir bar was also shown a high degree of selectivity toward L-glutamine compared to its isomer and analogues, while a reference stir bar prepared without the imprinting molecule was not shown any selectivity towards the enantiomers. Evidence was also presented by FT-IR analysis that the amide-hydrogen-bonding interaction between L-glutamine and amide groups in MIP-film was originated for L-glutamine recognition. The scanning electron microscope photographs showed that visible pores structure could be detected in the L-glutamine imprinted Nylon-6 film. Compared with traditional MIP and SBSE, the MIP-coated film showed not only the high selectivity, but also the rapid equilibrium adsorption.

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“…The MIPs can be used for the selective rebinding of the template. Special attention is drawn to the fact that MIPs are proven to be useful as chiral stationary phases (CSPs) [40][41][42][43][44], enabling their employment for the concentration of enantiomers. Although MIPs are used as stationary phases in HPLC, no publications have been found dealing with MIPs in on-line preconcentrating techniques.…”

Section: Mip Technologymentioning

confidence: 99%

On-line sample preconcentration in capillary electrophoresis, focused on the determination of proteins and peptides

Stroink

Paarlberg

Waterval³

et al. 2001

Electrophoresis

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This overview highlights the possibilities of on- or in-line preconcentration procedures in combination with a CZE separation, focused on the determination of peptides and proteins. The discussed methods, including sample stacking, field-amplified injection, isotachophoresis, solid phase extraction, membrane preconcentration, electroextraction, supported liquid membranes, hollow fibers, immunoaffinity, and molecularly imprinted polymers technology preconcentration are categorized in electrophoresis-based and chromatography-based preconcentration. The chromatography-based preconcentration is subdivided in low-specificity and high-specificity methods. A number of preconcentration methods are available, however, this paper demonstrates that various compounds in different media (aqueous solutions, urine, and plasma) require different preconcentration systems. The preconcentration techniques of first choice in general seem to be solid-phase extraction and membrane preconcentration, because of their high concentration ability, multiapplicability, relative simplicity and clean-up capability. For the future, hollow fibers seem to hold a great potential as preconcentration technique, yielding high concentration factors, using simple designs. New techniques, such as hollow fibers, molecularly imprinted polymers technology and supported liquid membranes may have the potential to supersede the conventional preconcentration techniques in some cases. The larger the arsenal of preconcentration techniques becomes, the more efficiently peptides and proteins may be analyzed in the future. These techniques, in some cases, require pre-cleanup procedures, to ensure the purity of the samples to concentrate.

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Recent advances in the preparation and use of molecularly imprinted polymers for enantiomeric resolution of amino acid derivatives

Cited by 86 publications

References 13 publications

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecular imprinted Nylon‐6 stir bar as a novel extraction technique for enantioseparation of amino acids

On-line sample preconcentration in capillary electrophoresis, focused on the determination of proteins and peptides

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