Recent Advances in the N-Aryl C—H Functionalization Using 7-Azaindole as Intrinsic Directing Group

Abstract

The intrinsic directing group is a functional group in the substrates and also serves as an essential component in products. Thus, the preinstallation and removal of directing groups are avoided. 7-Azaindole has been used as intrinsic directing group for the N-aryl-C-H functionalization of N-aryls under the catalysis of transition metals. Utilizing the C-H functionalization strategy, numerous functional groups were installed into the ortho-position of N-aryls of the corresponding N-aryl-7-azaindoles. In this review, the recent achievements on the transition-metal catalyzed N-aryl ortho-C-H functionalization directed by 7-azaindole are summarized.