Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review

High-performance liquid chromatographic separation of unusual β3-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases

“…Among the possible methods, enantioselective high-performance liquid chromatography (HPLC) is routinely used for the discrimination of enantiomers. Chromatographic enantioseparations of β-amino acids have been surveyed in several review articles (Hyun 2005;Ilisz et al 2008Ilisz et al , 2009Ilisz et al , 2012Lämmer-hofer 2010). The direct enantioresolution of β-amino acids has been successfully achieved with both low molecular Abstract Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β 3 -amino acid enantiomers containing, alkyl, aryl or heteroaryl sidechains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(−)™.…”

HIGH – PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ENANTIOSEPARATION OF UNDERIVATIZED Α-Amino ACIDS USING CYCLOFRUCTAN – BASED CHIRAL STATIONARY PHASES

“…Since most biologically important compounds exist in two enantiomeric forms that can possess differences in their physiological activity, the impetus for the separation of optical isomers and the preparation of enantiomerically pure compounds in the field of biotechnology, chemistry and pharmacology is still increasing (ILISZ et al, 2012). Chromatographic methods, i.e.…”

High‐performance liquid chromatographic enantioseparation of fluorinated cyclic β3‐amino acid derivatives on polysaccharide‐based chiral stationary phases. Comparison with nonfluorinated counterparts

“…The separation of enantiomers of unusual β-amino acids by high-performance liquid chromatography (HPLC) has been comprehensively investigated, and the results have been documented in several review papers (Ilisz et al, 2008(Ilisz et al, , 2010(Ilisz et al, , 2012a(Ilisz et al, , 2012b(Ilisz et al, , 2012c(Ilisz et al, , 2013. However, data relating to the HPLC analyses of fluorinated amino acids are very scarce, especially in the case of enantioseparation.…”