Recent Advances in the Diagnosis and Management of Malignant Pleural Effusions

Heffner, John E.; Klein, Jeffrey S.

doi:10.4065/83.2.235

Cited by 132 publications

(117 citation statements)

References 211 publications

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“…Despite advancement in different diagnostic tools and in the array of treatment options available today, effective treatment of pleural diseases such as malignant pleural mesothelioma, malignant pleural effusion and recurrent pneumothorax still remains challenging [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases

Qin

Jian

et al. 2011

Acta Pharmacol Sin

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Aim: To develop a method to deliver mesenchymal stem cells (MSCs) into the pleural cavity for the treatment of pleural diseases. Methods: MSCs were isolated from rat bone marrow of rats and labeled with 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI) or green fluorescent protein (GFP) using a lentiviral vector. Eighteen Sprague-Dawley (SD) rats were inoculated intrapleurally with 1×10 6 MSCs-DAPI. The distribution of the fluorescent cells was observed using fluorescent microscopy for the following 30 d. Another 12 rats inoculated intrapleurally with 1×10 6 MSCs-GFP were observed for 14 d. Results: The isolated cells were typical MSC phenotypes and could differentiate into adipocytes, osteoblasts, and chondroblasts in vitro. Microscopic analysis revealed that the labeled cells adhered to the surface of the pleural cavity. The highest number of the labeled cells was found to be adhered to all specimens from the mediastinal pleura, but no labeled cells were detected in the lung parenchyma or other tissues/organs, such as the liver, kidney, spleen, and mesenterium. Incidentally, stomas were found in the mediastinal pleura. The recovered MSCs-GFP from the pleural cavity retained their ability to adhere and proliferate. Conclusion: We have established a novel method for intrapleural delivery of MSCs. The distribution of intrapleurally delivered MSCs was found to be limited to the pleurae and the pleural cavity, thereby providing us with a new approach to further investigation of the therapeutic roles of MSCs in pleural diseases.

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Section: Introductionmentioning

confidence: 99%

Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases

Qin

Jian

et al. 2011

Acta Pharmacol Sin

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“…The annual incidence of MPE in the United States is about 150,000. More than 75% of MPEs are caused by neoplasms of the lung, breast, or ovary or by lymphoma (Hausheer and Yarbro, 1987;Henschke et al, 1991;Martinez-Moragon et al, 1998;Antunes and Neville, 2000;Heffner and Klein, 2008). However, the sensitivity of cytological examination in the detection of cancer cells is only approximately 65% (Nance et al, 1991;Starr and Sherman, 1991;Woenckhaus et al, 2005;Benlloch et al, 2006;Sriram et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A New Cancer Cell Detection Method Using an Infectivity-enhanced Adenoviral Vector

Uchino

Takayama

Nakagaki

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cytological examination is widely used as a diagnostic tool because of the ease of collecting cells from the involved area. However, the diagnostic yield of cytological examination is unsatisfactory; the reasons include sampling error, poorly prepared samples, small numbers of malignant cells, and low grades of cellular atypia. In this study, we focused on the high infectivity of adenovirus towards epithelial cells and applied the luciferaseexpressing adenoviral vector to a new cancer cell detection tool. In addition, adenoviral infectivity was enhanced by modifying viral fiber proteins. The sensitivity of the diagnostic tool was tested using the NCI-H1299 lung cancer cell line, and validated in body fluid samples from cancer patients with a variety of etiology. Results showed that the adenovirus efficiently transfected NCI-H1299 with high sensitivity. Only 10 cancer cells were sufficient for detection of luciferase signals. In body fluid samples, the adenovirus confirmed the diagnosis for malignant and benign cancer, but not in non-epithelial cell derived samples. This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer.

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“…One of the most frequent underlying causes is broncogenic carcinoma, especially lung adenocarcinoma. [1][2][3] The diagnosis of MPE is associated with advanced and disseminated disease and reduced life expectancy depending on the type and stage. [1][2][3] The current TNM classification of lung cancer has re-classified patients with metastasis, discriminating those having only pleural involvement from those with distant metastasis, as prognosis and survival differences exist between these two groups.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] The diagnosis of MPE is associated with advanced and disseminated disease and reduced life expectancy depending on the type and stage. [1][2][3] The current TNM classification of lung cancer has re-classified patients with metastasis, discriminating those having only pleural involvement from those with distant metastasis, as prognosis and survival differences exist between these two groups. 4 Biochemical characteristics of pleural fluid [5][6][7] and comorbidity 8 are also related to survival.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma

Botana-Rial

Chiara

Valverde

et al. 2012

Cancer Biology & Therapy

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Recent Advances in the Diagnosis and Management of Malignant Pleural Effusions

Cited by 132 publications

References 211 publications

Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases

Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases

A New Cancer Cell Detection Method Using an Infectivity-enhanced Adenoviral Vector

Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma

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