Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

Wang, Pengzhan; Yang, Huocheng; Liu, Chang; Qiu, Mingqiang; Ma, Xin; Mao, Zhiqiang; Sun, Yao; Liu, Zhihong

doi:10.1016/j.cclet.2020.11.056

Cited by 71 publications

(33 citation statements)

References 97 publications

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“…Some fluorescently labeled nanomaterials also have a significant role in tumor diagnosis and treatment, particularly those emitting second near-infrared channel (NIR-II) region fluorescence. Fluorescence imaging in the NIR-II region is at the forefront of biomedical research due to its inherent advantages, including relatively lower tissue autofluorescence and higher spatiotemporal resolution (132)(133)(134). Additionally, certain nanomaterials are constructed out of materials that respond to enzyme activity, and consequently, turn on quenched fluorescence under the catalysis of enzymes to obtain clear images (135).…”

Section: Nanodrugs Targeting Fap For Diagnosing and Treating Tumorsmentioning

confidence: 99%

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

et al. 2021

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Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma have an abundant and stable expression of FAP, which plays an important role in promoting tumor growth, invasion, metastasis, and immunosuppression. For example, in females with a high incidence of breast cancer, CAFs account for 50–70% of the cells in the tumor’s microenvironment. CAF overexpression of FAP promotes tumor development and metastasis by influencing extracellular matrix remodeling, intracellular signaling, angiogenesis, epithelial-to-mesenchymal transition, and immunosuppression. This review discusses the basic biological characteristics of FAP and its applications in the diagnosis and treatment of various cancers. We review the emerging basic and clinical research data regarding the use of nanomaterials that target FAP.

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Section: Nanodrugs Targeting Fap For Diagnosing and Treating Tumorsmentioning

confidence: 99%

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

et al. 2021

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“…To achieve this two-step theranostic, nanoparticles combined with both targeting imaging and multimodal therapy ability are highly needed in both lab-scale small animal models and clinical settings. In addition, the current instruments for NIR fluorophore detection mainly focus on the NIR-I window, and it is important to further move the NIR imaging-guided surgery to the NIR-II window with much improved imaging contrast and penetration depth ( Ding et al, 2019 ; Zhang et al, 2019 ; Li et al, 2020 ; Wang et al, 2020 ; Xu et al, 2020 ).…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Recent Progress in Nanomedicine for Melanoma Theranostics With Emphasis on Combination Therapy

Guan

Zhu

2021

Front. Bioeng. Biotechnol.

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Melanoma is an aggressive type of skin cancer with increasing incidence and high mortality rates worldwide. However, there is still a lack of efficient and resolutive treatment strategies, particularly in clinical settings. Currently, nanomedicine, an emerging area in the medical field, is being widely investigated in small animal models to afford melanoma theranostics. However, several problems, such as tumor heterogeneity, and drug resistance treatment with a single therapy, remain unresolved. Previous reviews have primarily focused on monotherapy for melanoma in the context of nanomedicine. In this review article, we summarize the recent progress in the application of nanomedicine for melanoma treatment, with particular attention to combination therapy based on nanomedicine to achieve optimized therapeutic output for melanoma treatment. In addition, we also highlight the fluorescence-guided strategies for intraoperative melanoma detection, especially in the near-infrared imaging window with greatly improved imaging contrast and penetration depth.

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“…The NPs utilized for OA imaging are mainly carbon-based NPs, for example, single-walled carbon nanotubes; metal-based NPs, for example, gold NPs; bismuth-based NPs; polymer-encapsulated organic NPs; semiconducting polymer NPs (SPNs); conjugated polymer; and novel DNA-based nanocarriers. ( Pu et al, 2014 ; Li and Chen, 2015 ; Weber et al, 2016 ; Yang et al, 2018 ; Yu et al, 2019 ; Zhan et al, 2019 ; Xu et al, 2020 ; Cheng et al, 2021 ; Fan et al, 2021 ; Joseph et al, 2021 ; Qi et al, 2021a ; Tuo et al, 2021 ; Wang et al, 2021a ; Wang et al, 2021b ; Zhen et al, 2021 ). NPs have the advantage of versatile multimodal imaging capacity, a favorable signal/noise ratio, high photothermal conversion, deep penetration depth with near-infrared (NIR) II probes, and diverse structure and types (activable, turnable, and metabolizable).…”

Section: Hybrid Contrast Agents For Multimodal Oa Brain Imagingmentioning

confidence: 99%

Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals

Shi

Kong

et al. 2021

Front. Bioeng. Biotechnol.

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Optoacoustic (photoacoustic) imaging has demonstrated versatile applications in biomedical research, visualizing the disease pathophysiology and monitoring the treatment effect in an animal model, as well as toward applications in the clinical setting. Given the complex disease mechanism, multimodal imaging provides important etiological insights with different molecular, structural, and functional readouts in vivo. Various multimodal optoacoustic molecular imaging approaches have been applied in preclinical brain imaging studies, including optoacoustic/fluorescence imaging, optoacoustic imaging/magnetic resonance imaging (MRI), optoacoustic imaging/MRI/Raman, optoacoustic imaging/positron emission tomography, and optoacoustic/computed tomography. There is a rapid development in molecular imaging contrast agents employing a multimodal imaging strategy for pathological targets involved in brain diseases. Many chemical dyes for optoacoustic imaging have fluorescence properties and have been applied in hybrid optoacoustic/fluorescence imaging. Nanoparticles are widely used as hybrid contrast agents for their capability to incorporate different imaging components, tunable spectrum, and photostability. In this review, we summarize contrast agents including chemical dyes and nanoparticles applied in multimodal optoacoustic brain imaging integrated with other modalities in small animals, and provide outlook for further research.

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Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

Cited by 71 publications

References 97 publications

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

Recent Progress in Nanomedicine for Melanoma Theranostics With Emphasis on Combination Therapy

Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals

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