Recent advances in the detection of drugs of abuse by dried blood spots

Abstract

The purpose of this review study was to sum up the main recent advances reported in the scientific literature about the detection of common drugs of abuse in biological samples upon their collection by dried blood spot devices. The most recent, innovative

Dried blood spot analysis with liquid chromatography and mass spectrometry: Trends in clinical chemistry

“…The use of DBS has been extensively reviewed [9–13]. The filter cards used can be chemically treated, for example, to preserve DNA (see Table 1 for a list of common commercially available filter cards).…”

“…As reviewed by Wagner et al, the expansion of MS based techniques, especially combined with electrospray ionization (ESI), was of particular importance for the growing use of DBS [9]. The use of DBS has been extensively reviewed [9][10][11][12][13]. The filter cards used can be chemically treated, for example, to preserve DNA (see Table 1 for a list of common commercially available filter cards).…”

New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR/MS) Combination

“…In addition to these analytical advances, the reduction in sample volume and the use of alternative matrices may be regarded as recent developments in the field of toxicological analysis. The use of alternative matrices, such as dried blood spots (DBS), has been reported for several years in different fields of toxicology including forensic [22], doping [22][23][24] and drug detection [22,25,26]. These systems have several advantages, including a low sampling volume and the fact that they are minimally invasive with facilitated transport and storage [25,26].…”

“…The use of alternative matrices, such as dried blood spots (DBS), has been reported for several years in different fields of toxicology including forensic [22], doping [22][23][24] and drug detection [22,25,26]. These systems have several advantages, including a low sampling volume and the fact that they are minimally invasive with facilitated transport and storage [25,26]. However, their use is generally limited to qualitative applications due to the inaccuracy in sampling volume [25,26].…”

“…These systems have several advantages, including a low sampling volume and the fact that they are minimally invasive with facilitated transport and storage [25,26]. However, their use is generally limited to qualitative applications due to the inaccuracy in sampling volume [25,26]. Indeed, the hematocrit value has been identified as the main cause of variability in the volume collected on DBS [27,28].…”