Recent Advances in the Chemistry and Synthetic Uses of Amino‐1,3,4‐thiadiazoles

Abstract

Amino‐1,3,4‐thiadiazoles, although scarce in nature, constitute a group of nitrogen and sulfur heterocyclic compounds that have shown significant biological activities. Their transformations into other biologically active compounds have been exploited. This review describes the work on the synthesis and reactions of amino‐1,3,4‐thiadiazoles as well as their biological evaluation.

An Easy Access to Construct Some New Fused 1,2,4‐Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

“…The experimental potential antitumor activity of the tested compounds reported in this study to their structures and the following structure activity relationships were postulated: (a) compound 6 contains two 1,2,4‐triazinothiadiazole moiety. (b) Also, in case for compounds 3 , 4 , and 5 , the high cytotoxic activity may be attributed to the presence of 1,2,4‐triazinothiadiazole moiety, which is in agreement with that reported . (c) Moreover, the high cytotoxic activity of compounds 7 and 9 may be attributed to the presence of 1,2,4‐triazino‐thiadiazine moiety (Figs.…”

“…1,3,4‐Thiadiazoles have been used in the pharmaceutical area as an antibacterial with known sulfonamide drugs, antimicrobial, antidepressant, antitumor, antioxidant, anti‐HIV, antileishmanial, antidiabetic, and anti‐inflammatory . Interesting biological activity of 1,3,4‐thiadiazole probably attributed to N–C–S linkage .…”

Synthesis and Antioxidant Activity of Some New Binary Pyrazoles Containing Core Phenothiazine Moiety

“…In view of the aforementioned facts and in continuation of our interest in the synthesis of biologically active heterocyclic , we report herein the synthesis and antioxidant evaluation of some novel pyrazoles incorporating phenothiazine moiety through different linkages. This combination was suggested in an attempt to investigate the influence of such hybridization and structure variation on the anticipated biological activities, hoping to reach a more potent antioxidant agent.…”

Highlights on the synthesis of novel phenothiazine‐based azines scaffold as antioxidant agents

“…Taking into account the mentioned findings and continuing our researches in synthesizing novel potent heterocycles of variable activities , it is reported herein the synthetic routes, structure characterization, and mechanistic pathways of phenothiazine analogs as novel antioxidant agents. The incorporation of azine heterocyclic systems into phenothiazine nucleus is useful to study the effect of these ring systems and structure relationship on the obtained antioxidant results with the hope to synthesize highly potent antioxidant compounds.…”