Recent Advances in the Chemistry of Benzo[b]furan and Its Derivatives. Part I: Occurrence and Synthesis

Cagniant, Paul; Cagniant, D.

doi:10.1016/s0065-2725(08)60132-4

Cited by 120 publications

(44 citation statements)

References 522 publications

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“…These kinds of naturally occurring compounds have attracted much attention from synthetic organic chemists, due to their interesting biological and pharmacological activities. [1][2][3] Several natural products bearing benzofuran and its derivatives as a moiety, [4][5][6] exhibit diverse biological activities such as being potent antibacterial, 7 antimicrobial, 8 antitumor, 9 anticonvulsant antiinammatory, 10 antidiabetic 11 and antineophobic agents.…”

Section: Introductionmentioning

confidence: 99%

Total synthesis of natural products containing benzofuran rings

et al. 2017

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Research on natural products containing benzofuran has remarkably increased during the past few decades.Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities. Several of such compounds have exhibited various biological activities, thus their total syntheses have attracted much attention from synthetic organic chemists. In this review, we aim to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures. Furthermore, we especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.

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Section: Introductionmentioning

confidence: 99%

Total synthesis of natural products containing benzofuran rings

et al. 2017

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“…9 We used this method for the synthesis of keto esters 2 and 4a-e starting from 1 alkyl 6 hydroxyben zo[cd]indol 2(1H) ones 1a,b (Scheme 1).…”

mentioning

confidence: 99%

Synthesis and structures of benzo[cd]furo[2,3-f]indol-4(5H)-one derivatives

et al. 2008

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A procedure was developed for the synthesis of derivatives of the new heterocyclic system, benzo[cd]furo[2,3 f]indole, based on the cyclodehydration of 6 acylmethyloxy 1 alkyl benzo[cd]indol 2(1H) ones. Either 7 or 8 aryl derivatives of benzo[cd]furo[2,3 f]indol 4(5H) ones can be prepared depending on the reaction conditions. The molecular and crystal structures of 7 and 8 phenylbenzo[cd]furo[2,3 f]indol 4(5H) ones were established by X ray diffraction.

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“…-Arenofurans have important biological and pharmacological activities [1 -4] and potential applications as fluorescent dyes and probes, and as photosensitizers [5] [6]. Among arenofurans, benzofurans have been the subject of the most extensive studies, and numerous synthetic methods have been developed for them [1] [2] [7 -9]. Compared to benzofurans, the reports on the synthesis of benzodifurans are rather limited [3] [7] [10].…”

Section: Synthesis Of Regioisomeric Functionalized Benzodifurans and mentioning

confidence: 99%

Synthesis of Regioisomeric Functionalized Benzodifurans and Angelicins

Quezada¹,

Delogu²,

Viña³

et al. 2009

Helvetica Chimica Acta

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Arenofurans have important biological and pharmacological activities. Compared to benzofurans, the reports on the synthesis of benzodifurans are rather limited. Here, we report the synthesis of a linear and an angular 3,3′‐bis(carboxymethyl)substituted benzodifuran and 4′‐carboxymethyl‐substituted angelicins from phloroglucinol, using 4‐halomethyl‐substituted dipyrones as key intermediates in the synthetic route. This strategy shows that the stability of a pyrone ring depends on the type of substituent at C(4) and the conditions used.

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Recent Advances in the Chemistry of Benzo[b]furan and Its Derivatives. Part I: Occurrence and Synthesis

Cited by 120 publications

References 522 publications

Total synthesis of natural products containing benzofuran rings

Total synthesis of natural products containing benzofuran rings

Synthesis and structures of benzo[cd]furo[2,3-f]indol-4(5H)-one derivatives

Synthesis of Regioisomeric Functionalized Benzodifurans and Angelicins

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