Recent advances in the catalytic synthesis of 3-aminooxindoles: an update

Abstract

<p>3-Substituted-3-aminooxindoles are versatile scaffolds and these motifs constitute the core structure of number of natural products and biologically active compounds.</p>

Accessing unnatural α-amino acids with tetrasubstituted stereogenic centersviacatalytic enantioselective reactions of ketimine-type α-iminoesters/α-iminoamides

“…Despite this, enantioselective chemistry, which relies on ketimines, including α-iminoesters, has become a hot research topic in organic chemistry over the past decade due to the benefits of ATAAs. 4–6…”

“…In this feature article, we focus on the catalytic enantioselective reactions of ketimine-type α-iminoesters or α-iminoamides with the aim of accessing unnatural ATAAs. Because the asymmetric reactions of isatin-derived α-iminoesters were reviewed by Chimni and co-workers in 2015, 2018, and 2020, 6 such reactions reported prior to 2020 are not included in this feature article.…”

Fluorenone Appended Colorimetric Sensor for Cascade Detection of Fluoride and Calcium Gluconate with Applications in Solid State and Logic Gate Systems

“…Now‐a‐days, huge interest has been paid to the molecular species that have the similar operations with electronic devices [24] . Such organic molecules find utilities in digital data‐processing, comparable to transistors in the usual electronic and have been widely used for the elaboration of simple and complex logic gates based on chemical/physical inputs [25–29] . Very recently, the advancements made in the smartphone technology has further progressed the areas of chemical and biological as it can support the researchers for the colorimetric analysis with the help of captured image quantification [30–31] .…”

Organocatalytic Direct Enantioselective Hydrophosphonylation of N-Unsubstituted Ketimines for the Synthesis of α-Aminophosphonates

“…Direct catalytic enantioselective addition to ketimines is an effective method for producing chiral amines with a tetrasubstituted carbon stereocenter under proton-transfer conditions. − The majority of the reactions use N -substituted ketimines, and the substituent on the nitrogen atom can tune reactivity and selectivity . However, these reactions require the protection and deprotection of the substituent to obtain N -unprotected amines, resulting in longer reaction steps and unwanted chemical waste formation.…”