Recent Advances in the C(sp²)-S Bond Formation Reactions by Transition Metal-Free C(sp²)-H Functionalization

Abstract

Aryl/vinyl thioethers containing C(sp 2)-S bonds are prevalent in biologically relevant molecules and compounds with other potential applications. Around the past decade, rapid progress has taken place in the research area of C(sp 2)-S construction, and a large number of efficient new catalytic systems as well as structurally versatile substrates have been identified for such reactions, which significantly enriched the content of the synthetic methodologies on C(sp 2)-S bond formation. This review introduces mainly the research advances on transition metal-free C(sp 2)-S bond forming reaction by means of C(sp 2)-H bond functionalization over the period of 2001～2016. Keywords transition metal-free; C(sp 2)-H bond; (Hetero)aryl; vinyl; C(sp 2)-S bond formation

Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides

“…More recently, the amination reaction has been modified and improved by using various metals as catalysts, including Cu, Pd, Fe, Ni, Ru, Co, and Ag . However, the use of metal catalyst is undesirable for the synthesis of pharmaceuticals, as the metal-catalyzed processes waste metal resources and increase the cost of the synthesis process . Consequently, the metal-free process for the synthesis of aromatic amines is attractive.…”

Synthesis of α-Keto Thioamides by Metal-Free C═C Bond Cleavage in Enaminones Using Elemental Sulfur

“…According to the chemical valence of the sulfur atom, the carbon–sulfur bonds are usually present in two different forms: the C–S single bond and the CS double bond. Because of the features of high stability and enriched pathways of bond formation, the construction of a single C–S bond is accessible via a large number of different synthetic approaches such as cross coupling, substitution and addition reactions, etc . On the contrary, as the other form of carbon–sulfur bond, the CS double bond has had fewer advances in terms of synthetic methodology.…”

Deposition of Fluorine-Containing Thin Film by Atmospheric Pressure Plasma Jet and Film Surface Structural Transition

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