Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

Akhter, Saima; Arman, Mitra; Tayab, Mohammed Abu; Islam, Mohammad Nazmul; Xiao, Jianbo

doi:10.1080/10408398.2022.2149466

Cited by 10 publications

(9 citation statements)

References 154 publications

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“…It is available for the quality control of Zhiqiao (medicinal citrus), with a specified content ≥3.0% (w/w) . In addition to the antidiabetic, antiobesity, anti-inflammatory, and anticancer effects of NEO, our previous studies suggested the effects of SYN and NEO on GO/MGO under high temperatures . Further, as reported, Citrus fruit extract (Citrus reticulata × Citrus sinensis and C.…”

Section: Introductionmentioning

confidence: 64%

“…24,25 NEO is one of the most abundant flavonoids in citrus, up to 218.9 mg/ g, 26 which could enhance fruity and citrus flavors and mask undesirable flavors. 27 It is available for the quality control of Zhiqiao (medicinal citrus), with a specified content ≥3.0% (w/ w). 23 In addition to the antidiabetic, antiobesity, antiinflammatory, and anticancer effects of NEO, 27 our previous studies suggested the effects of SYN and NEO on GO/MGO under high temperatures.…”

Section: ■ Introductionmentioning

confidence: 99%

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Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans

Liang,

Zhao,

et al. 2024

J. Agric. Food Chem.

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There is considerable research evidence that α-dicarbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO), are closely related to many chronic diseases. In this work, after comparison of the capture capacity, reaction pathway, and reaction rate of synephrine (SYN) and neohesperidin (NEO) on GO/MGO in vitro, experimental mice were administrated with SYN and NEO alone and in combination. Quantitative data from UHPLC-QQQ-MS/MS revealed that SYN/NEO/HES (hesperetin, the metabolite of NEO) could form the GO/MGO-adducts in mice (except SYN-MGO), and the levels of GO/MGOadducts in mouse urine and fecal samples were dose-dependent. Moreover, SYN and NEO had a synergistic scavenging effect on GO in vivo by promoting each other to form more GO adducts, while SYN could promote NEO to form more MGO-adducts, although it could not form MGO-adducts. Additionally, human experiments showed that the GO/MGO-adducts of SYN/NEO/HES found in mice were also detected in human urine and fecal samples after drinking flowers of Citrus aurantium L. var. amara Engl. (FCAVA) tea using UHPLC-QTOF-MS/MS. These findings provide a novel strategy to reduce endogenous GO/MGO via the consumption of dietary FCAVA rich in SYN and NEO.

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Section: Introductionmentioning

confidence: 64%

Section: ■ Introductionmentioning

confidence: 99%

Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans

Liang,

Zhao,

et al. 2024

J. Agric. Food Chem.

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“…It has also exhibited stress relief, hepatoprotective, anti‐allergic, antidiabetic, anti‐adipogenic, anti‐obesity, and immunomodulation activities [28] . Neohesperidin and vitexin are strong antioxidants and promising therapeutic candidates for the management of various etiologically complex diseases [29] . Neohesperidin has additionally been used as a template to produce hesperidine‐dihydrochalcone, a non‐caloric sweetener with added value for the food industry [29] .…”

Section: Resultsmentioning

confidence: 99%

“…Neohesperidin and vitexin are strong antioxidants and promising therapeutic candidates for the management of various etiologically complex diseases [29] . Neohesperidin has additionally been used as a template to produce hesperidine‐dihydrochalcone, a non‐caloric sweetener with added value for the food industry [29] . Diosmin has shown potent effects as a vasorelaxant agent alone or combined with hesperidin, it is considered a promising insulinogenic agent to treat DM2 [30] .…”

Section: Resultsmentioning

confidence: 99%

“…[29] Neohesperidin has additionally been used as a template to produce hesperidine-dihydrochalcone, a non-caloric sweetener with added value for the food industry. [29] Diosmin has shown potent effects as a vasorelaxant agent alone or combined with hesperidin, it is considered a promising insulinogenic agent to treat DM2. [30] Quercetin and rutin have shown outstanding properties as inhibitors of several enzymes involved in carbohydrate and lipid metabolism.…”

Section: Protective Effect Of Hybrid Films On the Nutraceutical Conte...mentioning

confidence: 99%

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“Delaying Rot Emergence in Persian Lime (Citrus×latifolia) Through Antifungal Hybrid Films Containing Litsea glaucescens Essential Oil”

Villa‐Ruano,

Evangelista‐Castro,

Coyotl‐Pérez

et al. 2024

Chemistry & Biodiversity

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Herein we describe the in situ inhibitory activity of three hybrid films (FL1, FL2, and FL3) against two wild strains of Colletotrichum gloeosporioides and Penicillium digitatum as causal agents of rot in Persian limes. The films FL2 and FL3 contained 1.0 and 1.3 % weight/volume Litsea glaucescens essential oil (LgEO) and significantly (p < 0.05) delayed rot emergence in Persian limes caused by both pathogens up to 10 days. The physicochemical properties of LgEO and hybrid films were obtained, whereas detailed HPLC profiling revealed that fruit covered with these films significantly (p < 0.01) preserved reducing sugars (sucrose, fructose, and glucose), organic acids (citric acid, ascorbic acid, malic acid, and oxalic acid), and flavonoids with nutraceutical activity (hesperidin, eriocitrin, naruritin, neohesperidin, diosmin, vitexin, rutin, and quercetin). This evidence sustains that the composites generated in this investigation improve the shelf life of Persian limes and conserve their nutraceutical content.

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Application of HPLC, LC-Q-TOF–MS, UF-HPLC and LC–MS in the comparative analysis of flavonoids and sterols in the Citrus paradise cv. shamber (grapefruit)

Ahmed,

Azmat,

Qayyum

et al. 2023

Rend. Fis. Acc. Lincei

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Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

Cited by 10 publications

References 154 publications

Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans

Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans

“Delaying Rot Emergence in Persian Lime (Citrus×latifolia) Through Antifungal Hybrid Films Containing Litsea glaucescens Essential Oil”

Application of HPLC, LC-Q-TOF–MS, UF-HPLC and LC–MS in the comparative analysis of flavonoids and sterols in the Citrus paradise cv. shamber (grapefruit)

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