Recent advances in the applications of CE to forensic sciences (2001–2004)

Tagliaro, Franco; Bortolotti, Federica

doi:10.1002/elps.200500697

Cited by 60 publications

(31 citation statements)

References 140 publications

(125 reference statements)

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“…A utilização dessa munição em especial tem se mostrado extremamente problemática de ser evidenciada pelos GSR inorgânicos, mesmo utilizando SEM/ EDX. 31 Dessa forma, pesquisadores têm utilizado novas metodologias para a caracterização dos resíduos orgânicos (pólvora) e inorgânicos (Figura 1b), 32 utilizando técnicas de separação como eletroforese 13,33 e cromatografia líquida 34 ou espectrometria atômica (fluorescência de raios-X, XRF, [35][36][37] além da espectrometria de massas com plasma indutivamente acoplado, ICP-MS, 38,39 espectrometria de massas de íons secundários 40 e espectrometria de absorção atômica). 41 A análise de drogas de abuso é uma das áreas que desperta grande interesse da comunidade científica no que tange à química forense.…”

Section: Introductionunclassified

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Romão¹,

Schwab²,

Bueno³

et al. 2011

Quím. Nova

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Section: Introductionunclassified

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Romão¹,

Schwab²,

Bueno³

et al. 2011

Quím. Nova

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“…All CE modes employ the same instrumentation; samples can be easily analyzed subsequently as diff erencing separation mechanisms. Generally, CE is a very promising tool for clinical analysis at the present time [14][15][16][17][18][19] and it could be a simple and less time-consuming alternative technique to HPLC and GC which are also based on diff erent separation mechanisms than CE. The selectivity of CE can be utilized for separation of complicated mixtures of target analytes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Capillary Electrophoresis as a Verification Tool for Immunochemical Drug Screening

Znaleziona¹,

Petr²,

Maier³

et al. 2007

BIOMED PAP

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Background:The aim of this work was to develop a simple capillary electrophoretic method as the verifi cation and confi rmation tool in the screening analysis for amphetamines, opiates, benzodiazepines and cocaine and their metabolites for toxicological applications.Methods: 50 mM phosphate Tris pH 2.0 with 30 % (v/v) of methanol was used as a background electrolyte that enabled fast separation of drugs and their metabolites in saliva and urine. Verifi cation of the data from the electrophoretic method was done by High Performance Thin Layer Chromatography (HPTLC) and the immunochemical screening test QuikScreen.Results: The experimental conditions of the Capillary Electrophoresis (CE) were partially optimized (mainly the infl uence of concentration and types of additives, e.g. cyclodextrines, organic solvents) and validated; the method was used for analysing samples from drug abusers.Conclusions: The non-instrumental, immunoassay tests could only confi rm qualitative addictions and are mainly employed when the emergency detection of drugs is needed. For quantitative analysis and verifi cation of obtained results the confi rmation step is strongly recommended. The simple screening capillary zone electrophoresis method allows recognition of the most abused drugs. The agreement of the results from CE, HPTLC and QuikScreen test was more than 95 %.

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“…Having been adopted in a wide range of applications [1][2][3], CE-MS has attracted increasing interest in the characterization of biological molecules such as proteins and peptides in complex matrices [4,5]. CE allows the rapid and efficient separation of these biological molecules with minimum sample preparation and sample consumption.…”

mentioning

confidence: 99%

Identifying bacterial species using CE–MS and SEQUEST with an empirical scoring function

Chen

et al. 2007

Electrophoresis

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CE-MS/MS analysis of proteolytic digests of bacterial cell extracts was combined with SEQUEST searching and a new scoring system to identify bacteria species in bacterial mixtures. Searches of MS/MS spectra against protein databases enabled the identification of bacterial species by the matching of the proteins associated with the corresponding species. An empirical scoring function was obtained by evaluating the SEQUEST search results of 38 samples that contained single bacterial species. The scoring by the empirical function helped move up the positive identification results from their original positions in the ranking based on Xcorr values alone. Therefore, the identification of bacteria in the samples that contained bacterial mixtures was improved. Bacterial species in 20 bacterial mixtures, including one real sample, were correctly identified by database searches and the new scoring function.

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Recent advances in the applications of CE to forensic sciences (2001–2004)

Cited by 60 publications

References 140 publications

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Química forense: perspectivas sobre novos métodos analíticos aplicados à documentoscopia, balística e drogas de abuso

Capillary Electrophoresis as a Verification Tool for Immunochemical Drug Screening

Identifying bacterial species using CE–MS and SEQUEST with an empirical scoring function

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