Recent advances in the application of acetophenone in heterocyclic compounds synthesis

Ziarani, Ghodsi Mohammadi; Kheilkordi, Zohreh; Mohajer, Fatemeh

doi:10.1007/s13738-019-01774-4

Cited by 22 publications

(3 citation statements)

References 127 publications

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“…The conducted research shows that components that could be used in various industries can be recovered from the waste, which is now completely thermally neutralized. Acetophenone is used in the perfume industry as an additive to soap, creams, perfumes, and detergents and also used as a catalyst in the polymerization of olefins, in organic synthesis as a photo-oxidant (Soucy 2014 ; Kaur et al 2019 ; Mohammadi Ziarani et al 2020 ; Nagarajan et al 2022 ). It is known that α-methylstyrene can be used as an additive to gasoline, or after hydrogenation to give cumene, which is used for the production of phenol (Mancuso et al 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Management of selected waste generated during cable production

Studziński,

Gackowska,

Dadzibóg

2023

Environ Sci Pollut Res

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The subject of the research was the recovery of raw materials from waste generated in the production of cable insulation and the management of aluminum sludge. It was found that 49% (w/w) acetophenone, 6.8% (w/w) α-methylstyrene, and 17.2% (w/w) cumyl alcohol can be recovered from waste with a loss on ignition of 95% and used in various industries. A gas chromatograph equipped with a mass spectrometry detector was used to identify the recovered compounds. A waste distillation process was proposed to remove the water layer and obtain a concentrated acetophenone fraction. A method of neutralizing the water fraction and distillation residues is presented. The proposed waste management method is an alternative method to the currently used thermal transformation method. In turn, aluminum sludge was used to produce aluminum sulfate, which was used in the plant’s sewage treatment plant as a coagulant. The effect of this action was a reduction of 67% in the content of total iron, 60% of trivalent iron, and 32% of chemical oxygen demand. The above-mentioned examples of waste management are part of a closed-loop waste management strategy.

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Section: Resultsmentioning

confidence: 99%

Management of selected waste generated during cable production

Studziński,

Gackowska,

Dadzibóg

2023

Environ Sci Pollut Res

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“…Acetophenone is the simplest aromatic compound composed of the benzene ring and ketone carbonyl, presenting a colorless or light-yellow liquid, and it is generally found in the volatile oil of plants [ 68 ]. Normally, OH groups at C2 and C4 connect with sugar groups among acetophenones isolated from CA , CB , and CW , such as bungeiside A-D and picein.…”

Section: Phytochemistrymentioning

confidence: 99%

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

et al. 2021

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Cynanchum auriculatum Royle ex Wight. (CA), Cynanchum bungei Decne. (CB) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are three close species belonging to the Asclepiadaceous family, and their dry roots as the bioactive part have been revealed to exhibit anti-tumor, neuroprotection, organ protection, reducing liver lipid and blood lipid, immunomodulatory, anti-inflammatory, and other activities. Until 2021, phytochemistry investigations have uncovered 232 compounds isolated from three species, which could be classified into C21-steroids, acetophenones, terpenoids, and alkaloids. In this review, the morphology characteristics, species identification, and the relationship of botany, extraction, and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species, are summarized for the first time, and their phytochemistry, pharmacology, and clinical safety are also updated. Moreover, the direction and limitation of current research on three species is also discussed.

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“…They are important intermediates for the synthesis of natural products and marketed drugs, and they find wide use in fields such as biology, pesticides, polymers, and materials science. Moreover, they are ideal synthons for multicomponent reactions, including three-and fourcomponent reactions, due to their commercial availability and accessibility [8]. Furthermore, highly functionalized acetophenone derivatives have interesting biological properties and are valuable compounds for supramolecular or medicinal chemistry [9].…”

Section: Introductionmentioning

confidence: 99%

Natural-derived acetophenones: chemistry and pharmacological activities

Ahmadpourmir,

Attar,

Asili

et al. 2024

Nat. Prod. Bioprospect.

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Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera Melicope (69) and Acronychia (44) were the principal species as producers of acetophenones. Graphical Abstract

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Recent advances in the application of acetophenone in heterocyclic compounds synthesis

Cited by 22 publications

References 127 publications

Management of selected waste generated during cable production

Management of selected waste generated during cable production

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

Natural-derived acetophenones: chemistry and pharmacological activities

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