Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress

Abstract

Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant‐derived molecules possessing various degrees of estrogen‐like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism. In this paper, we review the effects of phytoestrogens on human skin and the mechanisms by which phytoestrogens can alleviate the changes due to aging.

Perinatal exposure to a low dose of bisphenol-A advances pubertal spermatogenesis of F1 adolescent male rats

“…These ndings suggested that the perinatal BPA exposure increased the levels of ARC-kisspeptin mRNA probably through antagonizing the E2 activity in ARC. It has been well-recognized that phytoestrogens could exhibit either estrogenic or anti-estrogenic effects depending on the endogenous estrogen levels and ER expression in different tissues [36].…”

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

“…Phytoestrogens are a group of natural compounds, which have estrogen-like activity [160], with health benefits, such as a lowered risk of heart disease, breast and other hormone-dependent tumors, menopausal symptoms and osteoporosis. Three main categories of phytoestrogens, namely isoflavones, lignans and coumestans, are present in numerous vegetables (most notably soy), fruits and medicinal plants [161], and they are marketed as a natural alternative to estrogen replacement therapy.…”

“…Their activities are due to the structural similarity with 17-β-estradiol, the primary female sex hormone that promotes the interaction with the two main α and β estrogen receptors. Consequently, phytoestrogens can act as agonists, partial agonists and antagonists [160,163]. Some isoflavones and flavones isolated from the aerial parts of Genista morisii and Genista ephedroides were in vitro evaluated for their estrogenic [164] and anti-estrogenic activities [165] by a yeast-based estrogen receptor assay.…”

Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol

“…Isoflavones derived from soy beans have been widely used as potential anti-skin-aging compounds [ 5 , 6 ]. Numerous studies have reported that genistein, a major soy isoflavone, could suppress the generation of ROS and expression of MMP-1 and inducible nitrogen oxide synthase (iNOS), thereby exerting anti-wrinkle, skin-protective, and hydration effects against UV-induced photoaging [ 7 , 8 ]. However, due to its low skin permeability as well as low aqueous solubility, skin accumulation of genistein (NaCl solution; 140 mM) was only 0.1 μM per g of skin [ 9 ].…”