Recent advances in the analysis of antibiotics by CE and CEC

Castro-Puyana, María; Crego, Antonio L.; Marina, M. L.

doi:10.1002/elps.200900402

Cited by 30 publications

(21 citation statements)

References 71 publications

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“…Amino groups in the structure of antibiotics favor using ECL detection, and hence this detection system has been widely used in the determination of antibiotics . ECL detection is a kind of chemiluminescence where chemical luminescence emission is generated in the process of substance oxidation and reduction at an electrode surface.…”

Section: Ce With Other Spectroscopic Detection Systemsmentioning

confidence: 99%

“…The capacitively coupled contactless conductivity detector (C 4 D) has progressed in the last years and the number of applications of CE‐C 4 D has considerably increased in the field of antibiotic analysis as it can be observed in Table . C 4 D presents advantages as the non‐necessity of light absorption by the analytes, easy handling, reduced background noise (in comparison with normal conductivity detection) and robustness.…”

Section: Ce With Conductivity Detectionmentioning

confidence: 99%

“…This review covers all the literature concerning the separation and determination of antibiotics by CE from June 2011 to June 2013 as a continuation of previous reviews concerning this field . All CE modes are considered and the most significant applications of the developed methodologies are described.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in CE analysis of antibiotics and its use as chiral selectors

et al. 2014

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Antibiotics are a class of therapeutic molecules widely employed in both human and veterinary medicine. This article reviews the most recent advances in the analysis of antibiotics by CE in pharmaceutical, environmental, food, and biomedical fields. Emphasis is placed on the strategies to increase sensitivity as diverse off-line, in-line, and on-line preconcentration approaches and the use of different detection systems. The use of CE in the microchip format for the analysis of antibiotics is also reviewed in this article. Moreover, since the use of antibiotics as chiral selectors in CE has grown in the last years, a new section devoted to this aspect has been included. This review constitutes an update of previous published reviews and covers the literature published from June 2011 until June 2013.

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Section: Ce With Other Spectroscopic Detection Systemsmentioning

confidence: 99%

Section: Ce With Conductivity Detectionmentioning

confidence: 99%

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Recent advances in CE analysis of antibiotics and its use as chiral selectors

et al. 2014

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“…Comprehensive overviews of the articles published on the analysis of antibiotics by CE until June 2013 have been reported previously . The present review covers the most recent developments and applications of CE in the analysis of antibiotics grouping the articles published in the two‐year period between June 2013 and June 2015.…”

Section: Introductionmentioning

confidence: 98%

Analysis of antibiotics by CE and their use as chiral selectors: An update

2015

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The widespread use of antibiotics in medicine and as growth-promoting agents has increased the demand for suitable analytical techniques for their analysis. Analytical methods based on CE or miniaturized CE systems have proved over the years their ability for the analysis of antibiotics. Since our last review (Electrophoresis 2014, 35, 28-49) several new CE methodologies have been reported for antibiotic analysis. This review presents an update of the literature published from June 2013 to June 2015 for the analysis of antibiotics by CE. UV continues being the most used detection system for antibiotics analysis by CE. Strategies to improve sensitivity as the use of sensitive detection systems and the application of preconcentration techniques appear to be the major developments. Furthermore, the use of portable and miniaturized devices for antibiotic analysis is presented in detail. Applications of the developed methodologies to the determination of residues of antibiotics in biological, food, and environmental samples are carefully described. Finally, new developments and applications of antibiotics as chiral selectors in CE are also included.

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“…Analytical techniques including high performance liquid chromatography (HPLC) and gas chromatography (GC) allow the analysis of multiple analytes in the same extract when coupled to a mass spectrometer (MS), the combination of these techniques is commonly employed in environmental analyses [13,14,15,16,17,18,19]. However, detectors other than MS such as ultraviolet (UV), fluorescence (FL), chemiluminescence (CL) and other techniques such as capillary electrophoresis (CE) are also employed [20,21,22,23,24,25]. …”

Section: Introductionmentioning

confidence: 99%

Monitoring the Presence of 13 Active Compounds in Surface Water Collected from Rural Areas in Northwestern Spain

Iglesias

Nebot

Vázquez

et al. 2014

IJERPH

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Drug residues are considered environmental contaminants, and their occurrence has recently become a matter of concern. Analytical methods and monitoring systems are therefore required to control the continuous input of these drug residues into the environment. This article presents a suitable HPLC-ESI-MS/MS method for the simultaneous extraction, detection and quantification of residues of 13 drugs (antimicrobials, glucocorticosteroids, anti-inflammatories, anti-hypertensives, anti-cancer drugs and triphenylmethane dyes) in surface water. A monitoring study with 549 water samples was carried out in northwestern Spain to detect the presence of drug residues over two sampling periods during 2010, 2011 and 2012. Samples were collected from rural areas with and without farming activity and from urban areas. The 13 analytes were detected, and 18% of the samples collected showed positive results for the presence of at least one analyte. More collection sites were located in rural areas than in urban areas. However, more positive samples with higher concentrations and a larger number of analytes were detected in samples collected from sites located after the discharge of a WWTP. Results indicated that the WWTPs seems to act as a concentration point. Positive samples were also detected at a site located near a drinking water treatment plant.

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Recent advances in the analysis of antibiotics by CE and CEC

Cited by 30 publications

References 71 publications

Recent advances in CE analysis of antibiotics and its use as chiral selectors

Recent advances in CE analysis of antibiotics and its use as chiral selectors

Analysis of antibiotics by CE and their use as chiral selectors: An update

Monitoring the Presence of 13 Active Compounds in Surface Water Collected from Rural Areas in Northwestern Spain

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