Recent advances in synthesizing metal nanocluster-based nanocomposites for application in sensing, imaging and catalysis

Li, Shang; Jia-dong, XU; Nienhaus, G. Ulrich

doi:10.1016/j.nantod.2019.100767

Cited by 175 publications

(98 citation statements)

References 226 publications

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“…For instance, the design of nanostructures with a core–shell architecture is known to improve the physical and chemical properties of the composite by providing a protective interface to the NPs and combining other functionalities on a nanoscopic length scale. [ 158 ] Polymeric NPs and liposomes have traditionally been among the most commonly used materials for such purposes (see, e.g., Sailor et al). [ 159 ] More recently, metal–organic frameworks, dendrimers, and silica‐based inorganic hybrid NPs have been explored.…”

Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Casals

Zeng

Parra‐Robert

et al. 2020

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to contribute to improved treatments by the generation of new diagnostic and therapeutic products. In particular, inorganic nanoparticles (NPs) have emerged as flexible platforms to develop new imaging and therapy agents for detecting and treating diseases at its earliest stages, with benefits superior to any currently used treatments. [1] These materials have been reported as robust drug carriers, versatile scaffolds able to adjust conjugated biomolecules activity, and antennas that can be excited in biologically transparent media. [2] Besides, they can be easily detected and tracked in physiological environments due to their unique physicochemical signatures. [3] Thus, nowadays, with the requirements for more personalized treatments and precision medications, [4] the interest in these materials to develop multimodal/multifunctional nanosized particles that can perform diagnosis [5] and different therapies (such as chemo-, thermo-, radio-, immunotherapies) in a single nanoplatform [6] is continuously growing. [7] Among the broad range of newly proposed nanomaterials, antioxidant NPs add to this list of advantages that they even Antioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack of reproducibility of many studies, generate uncertainties delaying their effective implementation. Herein, the case of cerium oxide is considered, a well-known catalyst in the petrochemistry industry and one of the first antioxidant nanoparticles proposed for medicine. Like other nanoparticles, it is now described as a promising therapeutic alternative, now as threatening to health. Sources of these discrepancies and how this analysis helps to overcome contradictions found for other nanoparticles are summarized and discussed. For the context of this analysis, what has been reported in the liver is reviewed, where many diseases are related to oxidative stress. Since well-dispersed nanoparticles passively accumulate in liver, it represents a major testing field for the study of new nanomedicines and their clinical translation. Even more, many contradictory works have reported in liver either cerium-oxide-associated toxicity or protection against oxidative stress and inflammation. Based on this, finally, the intention is to propose solutions to design improved nanoparticles that will work more precisely in medicine and safely in society.

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Section: Toxicity and Safety: A Remaining Challengementioning

confidence: 99%

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Casals

Zeng

Parra‐Robert

et al. 2020

Small

110

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“…AuNCs with size blow 2 nm can easily enter the cell and adsorb on the biomembranes, which may improve the resolution of intracellular imaging and sensitivity of tissue imaging. 16 By rationally designing ligands and conjugating biomolecules, the intracellular distribution and specific binding of AuNCs can be regulated. Our group developed biligand engineered AuNCs that can assemble on the cell membranes and provide amplified signals for multimodal fluorescent imaging.…”

Section: Employing the Optical Properties For Biomedical Applicationsmentioning

confidence: 99%

“… 11 In particular, the combination of AuNCs with other nanomaterials can remarkably improve their optical properties. 16 Therefore, surface engineering of AuNCs is a promising strategy for achieving enhanced optical properties, such as strong intensity, good photostability, large Stokes shift, adjustable wavelength, and superior stability in a biosystem. 3 These performances are greatly desirable for biological applications.…”

Section: Introductionmentioning

confidence: 99%

Regulating the Optical Properties of Gold Nanoclusters for Biological Applications

et al. 2020

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Gold nanoclusters are promising optically functional materials because of their attractive optical properties, such as luminescence, two-photon absorption, photothermal conversion, and photodynamics. Regulating the optical functions of gold nanoclusters and improving their performance have attracted wide interest in biological applications. In this Review, we introduce the principles to manipulate both the intrinsic optical properties and the apparent optical performance of gold nanoclusters. Manipulating the surface ligands and compounding with other nanomaterials are facile and efficient strategies. Based on the regulated optical properties, the gold nanoclusters can be well applied in various biomedical applications from multimodal bioimaging toward theranostics. By correlating structures and optical properties, we expect a better utilization of the optical gold nanoclusters in the biological field.

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“…Due to their unique molecular structures and environmentally sensitive physicochemical properties (e.g., strong luminescence), metal NCs have gained marked acceptance in sensing applications. 30,198 The development of sensors relies heavily on the interactions/reactions of analytes with the metal NCs, which may cause measurable changes in the properties of the clusters. Based on the reactivity of metal NCs to selected ions, small molecules, and biomolecules, metal NCs have long been used as active probes for detecting and monitoring these species in the biomedical and environmental elds.…”

Section: Molecular Interactions/reactions In Sensing Applications Of mentioning

confidence: 99%

“…5,[25][26][27] More intriguingly, almost all these molecule-like properties show an atomic-level dependency on the cluster structure. Such structural dependency not only provides a good means to diversify cluster properties for practical applications in various elds (e.g., biomedicine, [28][29][30][31][32][33][34] green energy, [35][36][37] and catalysis), [38][39][40][41] but also offers an ideal platform for revealing the structure-property relationship of metal-based nanomaterials at the atomic level. 40,42,43 In the past few decades, the development of synthetic chemistry has allowed atomically precise [M n (SR) m ] q NCs to be widely used by the community as high-quality "metallic molecules", thus motivating various further developments of metal NCs such as self-assembly and practical application.…”

Section: Introductionmentioning

confidence: 99%

Molecular reactivity of thiolate-protected noble metal nanoclusters: synthesis, self-assembly, and applications

et al. 2021

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Recent advances in synthesizing metal nanocluster-based nanocomposites for application in sensing, imaging and catalysis

Cited by 175 publications

References 226 publications

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Regulating the Optical Properties of Gold Nanoclusters for Biological Applications

Molecular reactivity of thiolate-protected noble metal nanoclusters: synthesis, self-assembly, and applications

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