Recent advances in surface-enhanced Raman spectrometry for chemical analysis

Vo‐Dinh, Tuan; Alak, Ala; Moody, R.L.

doi:10.1016/0584-8547(88)80083-1

Cited by 54 publications

(22 citation statements)

References 21 publications

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“…These substrates consist of microplates, waveguides or optical fibers having silver-coated dielectric nanoparticles (30 nm diameter) (producing nanocaps or half-nanoshells) [12, 18], and nanorods [10]. The fabrication process involves depositing nanoparticles including polystyrene nanospheres [9, 11–14], titanium dioxide [15], alumina [16], and silica [18] on a solid substrate and then coating the nanoparticle base with a 50–100 nm layer of silver via vacuum thermal deposition. More recently, unique structures such as gold nanostars have been developed as plasmonics-active probes for SERS detection [21].…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1 shows some examples of SERS-active plasmonic platforms that have been developed for SERS applications: Substrates based on nanosphere arrays coated with silver [12]; (B) Nanocaps consisting of isolated nanospheres coated with silver; (C) Nanorod arrays fabricated using submicron lithography and plasma etching [10]; and (D) SERS-inducing fiber optic nanoprobe coated with silver nano-islands [22]. These plasmonics substrate platforms have led to a wide variety of analytical applications including sensitive detection of chemicals with both environmental, toxicological and biochemical significance – including polycyclic aromatic compounds [9,14], organophosphorus compounds [13], and DNA-adduct biomarkers [11]. We reported the first application of SERS in DNA probe technology in 1994 [17], and this early research has led to further development of the SERS method for medical diagnostics [18, 19, 23, 24].…”

Section: Introductionmentioning

confidence: 99%

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Plasmonic nanoprobes for SERS biosensing and bioimaging

Vo‐Dinh¹,

Wang

Scaffidi

2009

Journal of Biophotonics

200

122

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This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface-enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface-enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye-labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using “molecular sentinel” nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed. Plasmonic nanosensors and nanoprobes have been developed as sensitive and selective tolls for environmental monitoring, cellular biosensing, medical diagnostics and high throughput screnning.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasmonic nanoprobes for SERS biosensing and bioimaging

Vo‐Dinh¹,

Wang

Scaffidi

2009

Journal of Biophotonics

200

122

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“…Environmental Chemicals 3,4,6,15 Agricultural Products (Pesticides) 18 Pharmaceutical Products (Vitamins) 19 Biomedical Screening (DNA-adducts) 16,17 Remote Sensing (Fiberoptic monitor) 10,14 Cosmetics 20…”

Section: Areas Of Sers Detection and Applications Referencesmentioning

confidence: 99%

<title>Chemical monitors based on surface-enhanced raman scattering</title>

Vo‐Dinh

Alarie

Sutherland

et al. 1993

International Conference on Monitoring of Toxic Chemicals and Biomarkers

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This paper presents an overview of the development of chemical monitors using the SurfaceEnhanced Raman Scattering (SERS) technique. The SERS effect is based on recent experimental observations, which have indicated enhancement of the Raman scattering efficiency by factors up to 108 when a compound is adsorbed on rough metallic surfaces having submicron protrusions. The focus of our research efforts is on the development of SERS-active sensors and instrumentation capable of field analysis and remote sensing.

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“…[3][4][5] The Raman signals are enhanced by factors from 10 6 to 10 8 when the sample molecules are adsorbed on (or near) nanostructured surfaces or metal particles. We have developed such substrates in a variety of fashions, including silver-coated polystyrene, 6,7 fumed silica, 8 titanium dioxide, 9 and alumina. 10 Furthermore, these substrates have been applied to the detection of trace levels of environmentally significant compounds, such as polycyclic aromatic compounds, 11 organophosphorus compounds, 12 chlorinated pesticides, 13 fungicides, 14 and other growth inhibitors.…”

Section: Introductionmentioning

confidence: 99%