Recent Advances in Solid Phase Polymer Synthesis: Polyamides from Tailor-Made Building Blocks

Group interval-controlled polymers: an example of epoxy functional polymers via step-growth thiol–yne polymerization

“…To produce a well-defined polymer, various strategies, including living/control radical polymerization, iterative cycles, templates, and so on, have been identified. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Typically, using an iterative strategy, Merrifield synthesized sequence-defined polypeptides via a solid-phase synthesis technique, setting a precedent for sequence-controlled polymers. [4][5][6][7][8] Furthermore, several seminal works declared the successful structure control of man-made macromolecules by a nonenzymatic protocol, following a template polymerization mechanism.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Typically, using an iterative strategy, Merrifield synthesized sequence-defined polypeptides via a solid-phase synthesis technique, setting a precedent for sequence-controlled polymers. [4][5][6][7][8] Furthermore, several seminal works declared the successful structure control of man-made macromolecules by a nonenzymatic protocol, following a template polymerization mechanism. [15][16][17][18][19][20][21][22][23][24][25] Although solid-phase synthesis and template polymerization can offer precise sequences, they often have problems with scalable synthesis and/or structural diversity.…”