Recent Advances in Solid Dispersion Technology for Efficient Delivery of Poorly Water-Soluble Drugs

Abstract

Drug discovery is generally considered as a costly affair and it takes approximately 15 years to reach a new chemical entity into the market. Among the recent potent drug molecules with most effective pharmacological properties, very few reached for Phase I clinical trial in humans. Unfortunately, the historical average reveals an almost 90% overall attrition rate in clinical trials. The solubility and permeability of a drug are the critical factors influencing the success of a drug. Oral drug delivery systems still continue to exist as the most favored, simplest and easiest administration route. A huge number of potential clinical candidates won’t make it to the market or accomplish their maximum capacity except if their solubility and oral bioavailability are enhanced by formulation. The solubility of drugs will continue to exist as important aspects of formulation development. With the emergence of synthetic methods for new molecule synthesis in chemistry and better screening methods, the number of poorly water soluble compounds has dramatically expanded in the last few years. Solid dispersion is one of the most important techniques as it can be prepared by several methods. It is mostly prepared with a drug having poor water solubility and it explores hydrophilic polymers either individually or in combination for the enhancement of solubility. In comparison to the conventional formulations such as tablets or capsules, there are different methods with which solid dispersions can be prepared and also have many benefits over conventional drug delivery approaches. Solid dispersion systems are potential for increasing the solubility, oral absorption and bioavailability of drugs and the significance of the solid dispersion technology is constantly increasing. The main focus of this review is to present recent advancements in the area of solid dispersion. This review also includes an account of recent patents on solid dispersion and clinical status of solid dispersion based formulations.

RETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents

“…The term SD has been defined as a dispersion of one or more active moiety in a suitable inert carrier or matrix in a solidstate. It can be prepared by different formulation methodologies (Paudwal et al, 2019). The drug molecule can be dispersed in a different form to prepare the SDs.…”

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

“…Moreover, GBDP was prepared as the solid dispersions with polyethylene glycol 4000 by melting method. Solid dispersion is an efficient technology to improve solubilization and bioavailability of insoluble drugs including G. biloba leaf extract [ 19 ], whereas PEG 4000 is a commonly used carrier matrix for solid dispersion [ 20 , 21 ]. It has been demonstrated that G. biloba extract solid dispersions have higher dissolution and faster dissolution rate than natural extract [ 22 ].…”

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o

“…Alteration of the structure is thus, likely to reduce the antimicrobial efficacy. To increase the bioavailability of sc1o without reducing its antimicrobial efficacy, a suitable formulation such as solid dispersions, offers many benefits over conventional drug delivery approaches 18 .…”