Recent advances in SN-38 drug delivery system

Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors

“…SN38, known for its potent inhibition of DNA topoisomerase I [ 127 ], can induce apoptosis in CRC cells [ [128] , [129] , [130] ]. Similarly, SN38 encounters challenges related to its poor solubility and stability [ 131 ]. In contrast, chitosan possesses attributes such as water solubility, adhesion, and adsorption enhancement, rendering it suitable for encapsulating water-insoluble drugs within Ch-based NPs and facilitating efficient intestinal absorption [ [132] , [133] , [134] ].…”

Cyclodextrin Inclusion Complexes for Improved Drug Bioavailability and Activity: Synthetic and Analytical Aspects

“…The case of anti-cancer drugs is also relevant, as most of the cytotoxic compounds have very poor solubility and also poor penetrability in aqueous fluids, with most of them falling into BCS class IV, while also showing toxic effects even at low concentrations. Therefore, the role of natural, modified cyclodextrins and cyclodextrin-based polymers in their administration has been the subject of much research [ 40 , 41 , 42 , 43 ]. Moreover, many anti-tumor drugs are highly lipophilic and, therefore, even when administered intravenously, it is sometimes difficult to achieve the concentration required to achieve the desired effect.…”

Investigating the Impact of SN-38 on Mouse Brain Metabolism Based on Metabolomics

“…Irinotecan, a broad-spectrum cytotoxic anticancer drug, is widely used to treat various solid tumors and is frequently combined with other chemotherapeutic agents in treating cancers of the central nervous system (CNS).SN-38’s antitumor activity is 100 to 1000 times more potent than CPT-11, leading to its extensive study in various drug delivery and controlled release systems. 1 Several SN38 prodrugs, including DTS108, EZN-2208, and SN38 antibody-drug conjugates (ADCs) such as IMMU132 and IMMU130, are currently in clinical trials. 2 Previously, our team developed an effective antitumor drug release system, the SN-38 loaded PCL/GT electrospun film, and investigated its cytotoxicity against gliomas.…”