Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma

Tampa, Mircea; Georgescu, Simona Roxana; Mitran, Cristina Iulia; Mitran, Mădălina Irina; Matei, Clara; Scheau, Cristian; Constantin, Carolina; Neagu, Monica

doi:10.3390/jcm9093010

Cited by 16 publications

(20 citation statements)

References 107 publications

(135 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BCC displays a different behavior compared with other neoplasms; it has a slow evolution and metastasizes very rarely, but sometimes causes significant local damage. Chronic ultraviolet exposure, along with genetic factors, is the most important risk factor for the development of BCC [ 7 ]. Whole-exome sequencing to characterize the mutational landscape of sporadic BCCs has revealed that only Patched 1 ( PTCH1 ) is associated with a significant functional mutation burden.…”

Section: Discussionmentioning

confidence: 99%

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

Takada¹

2021

Case Rep Dermatol

View full text Add to dashboard Cite

In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated. Here, a case of sporadic BCC in an 80-year-old man is presented, and the effectiveness of SMO inhibitors in case of relapse is predicted. The aim of this study was to determine whether the SMO inhibitors can be effective in treating this individual should the tumor recur in the future. Immunohistochemistry (IHC) was performed in a tumor and the adjacent skin tissue from the patient. IHC within the same BCC tissue specimen revealed that Glioma-associated oncogene 1 (GLI1) and Smoothened (SMO) in the Hh signaling pathway and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the Wnt signaling pathway were overexpressed. Hh and Wnt signaling pathways were activated. These findings suggest that the patient might be resistant to treatment with SMO inhibitors because of the interaction between Hh and Wnt signaling pathways. Overexpression of GLI1 leads to transcriptional activation, making it an attractive molecular target for anticancer therapy owing to the downstream effectors of the cascade.

show abstract

Section: Discussionmentioning

confidence: 99%

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

Takada¹

2021

Case Rep Dermatol

View full text Add to dashboard Cite

show abstract

“…EGFR overexpression has been identified in various tumors, being involved in the modulation of various signaling pathways responsible for cell proliferation, invasion and metastasis. In BCC, the crosstalk between the EGFR and Hedgehog pathways induces the activation of RAS/MEK/ERK and JUN/AP-1 signaling [ 162 ].…”

Section: Uv Radiation As a Trigger For Mmp Productionmentioning

confidence: 99%

Current Perspectives on the Role of Matrix Metalloproteinases in the Pathogenesis of Basal Cell Carcinoma

et al. 2021

Self Cite

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) is the most common skin malignancy, which rarely metastasizes but has a great ability to infiltrate and invade the surrounding tissues. One of the molecular players involved in the metastatic process are matrix metalloproteinases (MMPs). MMPs are enzymes that can degrade various components of the extracellular matrix. In the skin, the expression of MMPs is increased in response to various stimuli, including ultraviolet (UV) radiation, one of the main factors involved in the development of BCC. By modulating various processes that are linked to tumor growth, such as invasion and angiogenesis, MMPs have been associated with UV-related carcinogenesis. The sources of MMPs are multiple, as they can be released by both neoplastic and tumor microenvironment cells. Inhibiting the action of MMPs could be a useful therapeutic option in BCC management. In this review that reunites the latest advances in this domain, we discuss the role of MMPs in the pathogenesis and evolution of BCC, as molecules involved in tumor aggressiveness and risk of recurrence, in order to offer a fresh and updated perspective on this field.

show abstract

“…Basal cell carcinoma (BCC) is the most common cutaneous malignancy [1]. The molecular pathogenesis of BCC is associated with the hedgehog signaling pathway and mutations in the patched homologue 1 (PCTH-1) transmembrane tumor-suppressing protein [2][3][4]. Several potential risk factors influence the development of BCC including exposure to ultraviolet radiation, genetic predisposition, genodermatoses, immunosuppression, and trauma [5].…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma associated with non-neoplastic cutaneous conditions: a comprehensive review

Cohen¹

2021

Dermatology Online Journal

View full text Add to dashboard Cite

show abstract

Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma

Cited by 16 publications

References 107 publications

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

Current Perspectives on the Role of Matrix Metalloproteinases in the Pathogenesis of Basal Cell Carcinoma

Basal cell carcinoma associated with non-neoplastic cutaneous conditions: a comprehensive review

Contact Info

Product

Resources

About