Recent advances in sample introduction for supercritical fluid chromatography

Kirschner, Cynthia Hume.; Taylor, Larry T.

doi:10.1002/jhrc.1240160203

Cited by 19 publications

(6 citation statements)

References 26 publications

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“…Furthermore, workers that are unable to achieve SFC precision on a par with GC and LC are often not aware of problems with their injection procedures. Reviews by Kirschner and Taylor (124) and Greibrokk (125) summarize packed-column and open-tubular SFC injection methods used by researchers.…”

Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

Supercritical Fluid Chromatography and Extraction

Chester¹,

Pinkston²,

Raynie³

1994

Anal. Chem.

163

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Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

Supercritical Fluid Chromatography and Extraction

Chester¹,

Pinkston²,

Raynie³

1994

Anal. Chem.

163

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“…Normally in SFC the fluid used as eluent is usually compressed above its critical pressure in order to attain the corresponding liquid state. It is pumped into the column and before entering the column it is heated above its critical temperature (Kirchner and Taylor 1993). Inside the column a constant pressure is maintained using the pressure restrictor present on the downstream side of the column or after the detector.…”

Section: Instrumentationmentioning

confidence: 99%

Supercritical Fluid Chromatography: A Green Approach for Separation and Purification of Organic and Inorganic Analytes

Datta

Auddy

2013

Green Chromatographic Techniques

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'Supercritical fluid' describes a gas or liquid at conditions above its critical point. A greater range of solvent properties can be achieved with Supercritical fluid as a single solvent by careful manipulation of temperature and pressure at the supercritical state. Supercritical fluids are attractive media for several chemical reactions having better control over the reaction rates in different areas of biochemistry, polymer chemistry and environmental science. Supercritical fluid extraction (SFE), a rapid, convenient, efficient, and selective method has been used successfully for the separation of analytes prior to supercritical fluid chromatography (SFC), which is a relatively recent chromatographic technique and is commercially available since 1982. SFC significantly reduces the usage of organic solvents and wastes by using supercritical CO 2 as the mobile phase. The important principles of green chemistry that are applicable to green chromatography includes prevention of waste, use of safer solvents and increasing energy efficiency. All these factors are taken care of in SFC which combines some of the best features of HPLC as well as GC. Analytes that cannot be vaporized for analysis by gas chromatography or have no functional groups for detection by the usual liquid chromatography techniques, can be separated and detected using SFC. By now SFC has been applied to wide variety of materials including natural products, pharmaceuticals, foods, pesticides, herbicides, surfactants, polymers and polymer additives, heavy metals, fossils fuels, petroleum, explosives and propellants. SFC has now become an attractive alternative for chiral drug separation.

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“…However, C could not be observed at retention gap temperatures above -55"C, at which temperature it then eluted on the tail Figure 4. Peak identijications: (1) n-decane, (2) n-dodecane, (3) n-tetradecane, (4) nheptadecane, (5) n-docosane, (6) n-tetracosane.…”

Section: N-tetradecane (3) N-heptadecane (4) N-docosane (5) N-tetrmentioning

confidence: 99%

“…An automated gas purging system has been developed by Berg et al [5]. The different liquid introduction techniques have been reviewed recently [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of solvent venting with a gas purge for the introduction of microliter sample volumes in supercritical fluid chromatography

Berg¹,

Hansen

Flaaten

et al. 1993

J Microcolumn Separations

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Abstract. Peak broadening and sample recovery are important considerations when working with large sample volume injections in capillary SFC. To measure possible contribution to peak broadening in the venting valve, a tee coupling was inserted between the retention gap and the column. A standard sample containing glyceryl esters was injected. Based on time variance measurements, the venting valve did not lead to measurable band broadening. Recovery was found to be dependent on the length of the retention gap, the C02/He ratio in the purge gas, and the temperature of the retention gap. Cryofocusing was needed to increase the recoveries of volatile n-alkanes. To increase the recoveries of glyceryl esters, an enhanced C02/He ratio was needed.

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Recent advances in sample introduction for supercritical fluid chromatography

Cited by 19 publications

References 26 publications

Supercritical Fluid Chromatography and Extraction

Supercritical Fluid Chromatography and Extraction

Supercritical Fluid Chromatography: A Green Approach for Separation and Purification of Organic and Inorganic Analytes

Evaluation of solvent venting with a gas purge for the introduction of microliter sample volumes in supercritical fluid chromatography

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