Recent Advances in Role of Matrix metalloproteinases in Some Dental Diseases

MH, Javed; Sabahat, Hameed

doi:10.19070/2377-8075-1600070

Cited by 1 publication

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References 30 publications

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“…Normal cells protect themselves from oxidative stress using both enzymatic and non-enzymatic antioxidants, with the former including superoxide dismutase (SOD), glutathione peroxidase (GPX), myeloperoxidase, and catalase and the latter vitamins, minerals, polyphenols and thiols [ 15] . Javed, et al [ 16] stated that MMPs are enzymes that not only degrade collagens and extracellular matrix (ECM) proteins but can also regulate the activity of many bioactive molecules, like cell surface receptors and the release of apoptotic ligands . Thus, both ROS and MMPs interact together to cause tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Awwad

2020

Egyptian Dental Journal

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Introduction: Aging greatly diminishes the ability of oral tissues to withstand various types of functional insults, and reduces cell regeneration. Hence, anti-oxidation is mandatory to preserve oral tissues especially while aging. Melatonin is an anti-oxidant with established potential in hindering age-related changes. Aim: to evaluate the extent of anti-oxidant and anti-inflammatory potentials of melatonin on aged hard palatal tissues of rats. Materials and Methods: twenty-one Albino rats 200-250 gms each, were used in this study. They were equally divided into 3 groups; Control Young Gp: 6 months of age, Control Senile Gp:18 months of age, and Melatonin Gp: 18 months of age. After 8 weeks, rats were sacrificed by high dose of anesthesia. The hard-palatal mucosae of all rats were separated and processed for histologic examination by H&E, Masson Trichrome stain, and immuno-histochemical staining by Anti-PCNA, then examined by light microscopy. Results: the control senile Gp showed statistically significant increase in vacuolated epithelial cells and area percentage of mature collagen fibers, as well as statistically significant reduction in PCNA-positive cells and apparent reduction of epithelial thickness. On the other hand, the melatonin Gp displayed statistically significant increase in PCNA-positive cells, area percentage of immature collagen fibers, while significant decrease in No. of vacuolated epithelial cells and apparent increase of epithelial thickness. Discussion: Aging resulted in deteriorated regeneration, enhanced apoptosis, with reduced cellularity and vascularity. On the other hand, melatonin greatly improved cellular proliferation, reduced apoptosis, enhanced CT tissue regeneration and collagen production. As well as reduction in inflammatory cells.

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Section: Discussionmentioning

confidence: 99%

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Awwad

2020

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

Recent Advances in Role of Matrix metalloproteinases in Some Dental Diseases

Cited by 1 publication

References 30 publications

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

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