Recent advances in responsive antibacterial materials: design and application scenarios

Zhang, Bo; Lu, Derong; Duan, Hongwei

doi:10.1039/d2bm01573k

Cited by 17 publications

(9 citation statements)

References 215 publications

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“…In contrast to conventional therapeutic agents, these smart biomaterials exhibit a remarkable ability to selectively respond to both external triggers and intricate microenvironmental cues, thus enabling tailored intervention for inflammatory bone loss. [67][68][69] Intelligent biomaterials are mainly based on stimuli-responsive biomaterials, which can be categorized into two distinct groups: exogenous stimuli-responsive biomaterials and microenvironmental stimuli-responsive biomaterials. Exogenous stimuli-responsive biomaterials primarily encompass light-responsive (carbon-based nanomaterials, gold, graphite carbon nitride, transition metal dichalcogenides, upconversion nanoparticles, etc.…”

Section: Biomaterials For Inflammatory Bone Lossmentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon us more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, we list the advances of biomaterials for ameliorating inflammatory bone loss. Additionally, we summarize the advantages and disadvantages of various biomaterials‐mediated strategies. Finally, we analyze the challenges and perspectives of biomaterials. This review aims to provide new possibilities for developing more advanced biomaterials towards inflammatory bone loss.This article is protected by copyright. All rights reserved

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Section: Biomaterials For Inflammatory Bone Lossmentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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“…Acid (4). The ethyl ester from above (0.0811 g, 0.151 mmol) and lithium hydroxide (0.594 g, 24.8 mmol) were dissolved in water (5 mL) and methanol (15 mL).…”

Section: Synthesis Of 7-(4-(((4-azidobenzyl)oxy)carbonyl)piperazin-1y...mentioning

confidence: 99%

Site-Specific Antimicrobial Activity of a Dual-Responsive Ciprofloxacin Prodrug

Ross,

Lawer,

Sircombe

et al. 2024

J. Med. Chem.

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Bacterial infections create distinctive microenvironments with a unique mix of metabolites and enzymes compared with healthy tissues that can be used to trigger the activation of antibiotic prodrugs. Here, a single and dual prodrug masking the C3 carboxylate and C7 piperazine of the fluoroquinolone, ciprofloxacin, responsive to nitroreductase (NTR) and/or hydrogen sulfide (H2S), was developed. Masking both functional groups reduced the activity of the prodrug against Staphylococcus aureus and Escherichia coli, increasing its minimum inhibitory concentration (MIC) by ∼512-fold (S. aureus) and ∼8000-fold (E. coli strains), while masking a single group only increased the MIC by ∼128-fold. Bacteria subjected to prolonged prodrug exposure did not show any increase in resistance. Triggering assays demonstrated the conversion of prodrugs to ciprofloxacin, and in a murine infection model, responsive prodrugs showed antibacterial activity comparable to that of ciprofloxacin, suggesting in vivo activation of prodrugs. Thus, the potential for site-specific antibiotic treatment with reduced threat of resistance is demonstrated.

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“…and extrinsic (temperature, light, ultrasound, mechanical force, electric or magnetic fields, etc. ) signals 189 would surely stand for ground-breaking era regarding the impactful antimicrobial action of dental hydrogels. Antimicrobial bioinks such as chitosan could also be incorporated into these formulations to trigger inherent antimicrobial action, besides the multifunctionality of hydrogels.…”

Section: Challenges and Future Prospectsmentioning

confidence: 99%