Recent advances in regulatory T cells induced by B cells

Chien, Chien-Hui; Chiang, Bor‐Luen

doi:10.1038/cmi.2017.130

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Also in agreement with our results a recent study showed that patients with X-linked agammaglobulinemia mounted a stronger T cell response to SARS-CoV-2 vaccination compared to healthy controls [22] . Possible mechanisms underlying this finding include depletion of regulatory B cells, alleviating their inhibition of T cell activation [23] , decreased activation of regulatory T cells in the absence of B cells [24] , or alterations in the local inflammatory milieu at the site of vaccination.…”

Section: Discussionmentioning

confidence: 99%

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Gadani¹,

Reyes‐Mantilla²,

Jank³

et al. 2021

EBioMedicine

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Section: Discussionmentioning

confidence: 99%

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Gadani¹,

Reyes‐Mantilla²,

Jank³

et al. 2021

EBioMedicine

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“…Moreover, a specialized subset of Tregs, termed T follicular regulatory cells (T fr ), has been identified close to lymph follicles that suppress Tfh and germinal center responses [ 180 , 181 ]. Recent studies indicate that B cells, in turn, are able to induce Tregs (CD4 + CD25 + Foxp3 − ) cells, which have been named Treg-of-B cells [ 182 ] and play a protective role in several inflammatory mouse models. It remains to be determined how Tregs and ex-Tregs with attenuated Treg phenotype (Th17/Tregs [ 183 ], Tfh/Tregs [ 152 ], and Th1/Tregs [ 184 ]) influence the activity of different B cell subsets in atherosclerosis.…”

Section: Antigen Presentation and Co-stimulatory Moleculesmentioning

confidence: 99%

Functional Role of B Cells in Atherosclerosis

Shelby

Mußbacher

Galkina

2021

Cells

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Atherosclerosis is a lipid-driven inflammatory disease of blood vessels, and both innate and adaptive immune responses are involved in its development. The impact of B cells on atherosclerosis has been demonstrated in numerous studies and B cells have been found in close proximity to atherosclerotic plaques in humans and mice. B cells exert both atheroprotective and pro-atherogenic functions, which have been associated with their B cell subset attribution. While B1 cells and marginal zone B cells are considered to protect against atherosclerosis, follicular B cells and innate response activator B cells have been shown to promote atherosclerosis. In this review, we shed light on the role of B cells from a different, functional perspective and focus on the three major B cell functions: antibody production, antigen presentation/T cell interaction, and the release of cytokines. All of these functions have the potential to affect atherosclerosis by multiple ways and are dependent on the cellular milieu and the activation status of the B cell. Moreover, we discuss B cell receptor signaling and the mechanism of B cell activation under atherosclerosis-prone conditions. By summarizing current knowledge of B cells in and beyond atherosclerosis, we are pointing out open questions and enabling new perspectives.

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“…Evidence suggests that resting B cells expand and maintain Treg populations in the presence of TGF‐β or allogeneic response 10,11,34 . Previously, our group reported that B cells derived from the spleen, peritoneal cavity and Peyer's patches have the capacity to induce CD4 + CD25 + FoxP3 − Treg cells in vitro; thus, we termed them ‘Treg‐of‐B cells’ 35,36 . Treg‐of‐B cells protect mice from Th2‐mediated allergic inflammation, 14 modulate the Th1 response and alleviate collagen‐induced arthritis 17 .…”

Section: Discussionmentioning

confidence: 99%

“… 10 , 11 , 34 Previously, our group reported that B cells derived from the spleen, peritoneal cavity and Peyer's patches have the capacity to induce CD4 + CD25 + FoxP3 − Treg cells in vitro; thus, we termed them ‘Treg‐of‐B cells’. 35 , 36 Treg‐of‐B cells protect mice from Th2‐mediated allergic inflammation, 14 modulate the Th1 response and alleviate collagen‐induced arthritis. 17 Furthermore, Treg‐of‐B cells suppress Th1 and Th17 responses during intestinal inflammation.…”

Section: Discussionmentioning

confidence: 99%

M2‐like macrophages polarized by Foxp3⁻Treg‐of‐B cells ameliorate imiquimod‐induced psoriasis

Huang

Lin

Wang

et al. 2023

J Cellular Molecular Medi

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Our group have demonstrated that splenic B cells contributed to the CD4+CD25− naive T cells conversion into CD4+CD25+Foxp3− regulatory T cells without adding appended cytokines, named Treg‐of‐B cells which were potent suppressors of adaptive immunity. We like to investigate whether Treg‐of‐B cells could promote alternatively activated macrophage (M2 macrophages) polarization and alleviate inflammatory disease, psoriasis. In this study, we co‐cultured the bone marrow‐derived macrophages (BMDMs) with Treg‐of‐B cells under LPS/IFN‐γ stimulation and analyzed the M2‐associated gene and protein using qPCR, western blotting, and immunofluorescence staining. We also examined the therapeutic effect of Treg‐of‐B cell‐induced M2 macrophage for skin inflammation using imiquimod (IMQ)‐induced psoriatic mouse model. Our results showed that BMDMs co‐cultured with Treg‐of‐B cells upregulated typical M2‐associated molecules, including Arg‐1, IL‐10, Pdcd1lg2, MGL‐1, IL‐4, YM1/2 and CD206. In an inflammatory environment, TNF‐α and IL‐6 production by macrophages co‐cultured with Treg‐of‐B cells was decreased significantly. The molecular mechanism revealed that Treg‐of‐B cells promoted M2 macrophage polarization via STAT6 activation in a cell contact‐dependent manner. Moreover, the treatment with Treg‐of‐B cell‐induced M2 macrophages attenuated the clinical manifestations of psoriasis, such as scaling, erythema and thickening in the IMQ‐induced psoriatic mouse model. T cell activation in draining lymph nodes was decreased in the Treg‐of‐B cell‐induced M2 macrophage group after IMQ application. In conclusion, our findings suggested that Foxp3− Treg‐of‐B cells could induce alternatively activated M2 macrophages through STAT6 activation, providing a cell‐based therapeutic strategy for psoriasis.

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Recent advances in regulatory T cells induced by B cells

Cited by 8 publications

References 10 publications

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Functional Role of B Cells in Atherosclerosis

M2‐like macrophages polarized by Foxp3⁻Treg‐of‐B cells ameliorate imiquimod‐induced psoriasis

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Recent advances in regulatory T cells induced by B cells

Cited by 8 publications

References 10 publications

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Functional Role of B Cells in Atherosclerosis

M2‐like macrophages polarized by Foxp3−Treg‐of‐B cells ameliorate imiquimod‐induced psoriasis

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M2‐like macrophages polarized by Foxp3⁻Treg‐of‐B cells ameliorate imiquimod‐induced psoriasis