Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy

Rabiee, Navid; Yaraki, Mohammad Tavakkoli; Garakani, Soha Mokhtari; Garakani, Shima Mokhtari; Ahmadi, Sepideh; Lajevardi, Aseman; Bagherzadeh, Mojtaba; Rabiee, Mohammad; Tayebi, Lobat; Tahriri, Mohammadreza; Hamblin, Michael R.

doi:10.1016/j.biomaterials.2019.119707

Cited by 151 publications

(125 citation statements)

References 195 publications

(210 reference statements)

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“…Normally anti-infective agents need to be delivered at a high dosage into the body for an effective treatment. 220 − 222 However, most of the drug delivery systems have toxicity at their high concentrations. Recently, fluorescent nanomaterials with excellent antibacterial and bacteria targeting functions have been explored.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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The COVID-19 outbreak has exposed the world’s preparation to fight against unknown/unexplored infectious and life-threatening pathogens. The unavailability of vaccines, slow or sometimes unreliable real-time virus/bacteria detection techniques, insufficient personal protective equipment (PPE), and a shortage of ventilators and many other transportation equipments have further raised serious concerns. Material research has been playing a pivotal role in developing antimicrobial agents for water treatment and photodynamic therapy, fast and ultrasensitive biosensors for virus/biomarkers detection, as well as for relevant biomedical and environmental applications. It has been noticed that these research efforts nowadays primarily focus on the nanomaterials-based platforms owing to their simplicity, reliability, and feasibility. In particular, nanostructured fluorescent materials have shown key potential due to their fascinating optical and unique properties at the nanoscale to combat against a COVID-19 kind of pandemic. Keeping these points in mind, this review attempts to give a perspective on the four key fluorescent materials of different families, including carbon dots, metal nanoclusters, aggregation-induced-emission luminogens, and MXenes, which possess great potential for the development of ultrasensitive biosensors and infective antimicrobial agents to fight against various infections/diseases. Particular emphasis has been given to the biomedical and environmental applications that are linked directly or indirectly to the efforts in combating COVID-19 pandemics. This review also aims to raise the awareness of researchers and scientists across the world to utilize such powerful materials in tackling similar pandemics in future.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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“…Gold nanoparticles (AuNPs) are used in cancer diagnosis and biological imaging because of their excellent optical properties, low cytotoxicity, and good biocompatibility [ 1 , 2 , 3 , 4 , 5 ]. As potential drug carriers, AuNPs have received considerable attention by many researchers [ 6 , 7 , 8 , 9 , 10 ], as it has been frequently reported that they can induce programmed cell death (i.e., apoptosis) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Ren

Yang

et al. 2021

Pharmaceuticals

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Functionalized gold nanoparticles (AuNPs) have been successfully used in many fields as a result of having low cytotoxicity, good biocompatibility, excellent optical properties, and their ability to target cancer cells. Here, we synthesized AuNP carriers that were modified by hyaluronic acid (HA), polyethylene glycol (PEG), and adipic dihydrazide (ADH). The antitumor drug doxorubicin (Dox) was loaded into AuNP carriers and attached chemically. The Au nanocomposite AuNPs@MPA-PEG-HA-ADH-Dox was able to disperse uniformly in aqueous solution, with a diameter of 15 nm. The results of a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that AuNP carriers displayed very little toxicity toward cells in high doses, although the antitumor properties of Au nanocomposites were significantly enhanced. Cellular uptake experiments demonstrated that AuNPs modified with hyaluronic acid were more readily ingested by HepG2 and HCT-116 cells, as they have a large number of CD44 receptors. A series of experiments measuring apoptosis such as Rh123 and annexin V-FITC staining, and analysis of mitochondrial membrane potential (MMP) analysis, indicated that apoptosis played a role in the inhibition of cell proliferation by AuNPs@MPA-PEG-HA-ADH-Dox. Excessive production of reactive oxygen species (ROS) was the principal mechanism by which the Au nanocomposites inhibited cell proliferation, leading to apoptosis. Thus, the Au nanocomposites, which allowed cell imaging in real-time and induced apoptosis in specific cell types, represent theragnostic agents with potential for future clinical applications in bowel cancer.

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“…They also can be used as a diagnostic gadget and therapeutic "doer". [1][2][3][4] The results from many types of research showed that the specific structural characteristics of these molecules have opened new research fields leading to the design of aptamers. Aptamers are oligonucleotides including ssRNA, ssDNA (single-stranded RNA, DNA) or peptides that bind to select targets with significant dependency and exclusivity due to their specific structural characteristics.…”

Section: Introductionmentioning

confidence: 99%

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

Rabiee¹,

Ahmadi²,

Arab³

et al. 2020

IJN

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With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.

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Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy

Cited by 151 publications

References 195 publications

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

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