“…The intelligent selection of biomes/biome-extracted precursors for nanosystem fabrication can be used to control the surface functionalities, optimizing band structures and band gaps, morphological and topological features, ambient and hostile environment stabilities, biocompatibility, toxicity and bioaccumulation for targeted solutions. In recent years, various targeted green nanosystems have been engineered for combatting NDDs, including implantable and diagnostic devices like catheters, biosensors and stunts, drug delivery like nanoliposomes with potential to be functionalized with antibodies and crossing BBB, developing immunity and nanoscaffolds for neurogeneration, controlling and curing primary and secondary symptoms, biocompatibility in surgical prostheses, and targeted therapeutics and imaging eliminating systemic toxicity (Mizrahi et al, 2014;Santhoshkumar et al, 2014;Charbgoo et al, 2017;Maddinedi et al, 2017;Suganthy et al, 2018;Kotcherlakota et al, 2019;Zhang et al, 2020;Ahlawat and Narayan, 2021;Jan et al, 2021;Pathania et al, 2022bPathania et al, , 2022aCui et al, 2022;Jasim et al, 2022;Kokturk et al, 2022;Monika et al, 2022). Moreover, their indirect utilization for strengthening present NDD monitoring strategies, such as enhancing the monitoring performance of microelectrodes utilized in electrophysiology, improving lasermediated vascular anastomoses, and enhancing optical interfaces for neural imaging, is combatting the bottlenecks of controlled monitoring of neuronal ensembles.…”