Recent advances in polysaccharides from the genus Polygonatum: Isolation, structures, bioactivities, and application

Hu, Yunfei; Tang, Yuling; Zhang, Zhiyong; Guo, Xuting; Wu, Ziyi; Li, Zheng; Yu, Han‐Qing; Li, Wenlong

doi:10.1016/j.foodhyd.2023.108634

Cited by 15 publications

(2 citation statements)

References 63 publications

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“…Polygonatum, a widely recognized medicinal and edible plant, has been demonstrated to possess various biological activities and a potentially significant market status [41,42].…”

Section: Discussionmentioning

confidence: 99%

Combined Metabolomics and Transcriptomics Analysis of the Distribution of Flavonoids in the Fibrous Root and Taproot of Polygonatum kingianum Coll.et Hemsl

Mo,

Wang,

et al. 2024

Genes

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Polygonati rhizoma, known for its distinct yellow rhizomes, is a common therapeutic and culinary plant in Far East Asia. The hue of medicinal plants is closely tied to the flavonoid biosynthesis and content levels. In this research, the fibrous root and taproot of Polygonatum kingianum Coll.et Hemsl. were studied to explore the secondary metabolite expression and flavonoid biosynthesis mechanisms using transcriptomics and metabolomics. Metabolic analysis identified that the differentially accumulated metabolites (DAMs) in the fibrous root and taproot were predominantly flavonoids, steroids, alkaloids, and phenolic acids. Overall, 200 flavonoids were identified in P. kingianum Coll.et Hemsl., with 170 exhibiting variances between the fibrous root and taproot. The transcriptome analysis revealed that a total of 289 unigenes encoding 32 enzymes were annotated into four flavonoid biosynthesis pathways, which include phenylpropanoid biosynthesis pathway, flavonoid biosynthesis pathway, isoflavonoid biosynthesis pathway, and flavone and flavonol biosynthesis pathway. The integration of transcriptomic and metabolomic data elucidated that the 76 differentially expressed genes (DEGs) encoding 13 enzyme genes (HCT, CCOMT, C4H, C3′H, CHI, PGT1, FLS, F3′H, CHS, ANR, DFR, F3′5′H, and LAR) and 15 DAMs preferred to be regulated in the flavonoid biosynthesis pathway. The expression of 10 DEGs was validated by qRT-PCR, agreeing with the same results by RNA-Seq. These findings shed light into the biosynthesis of secondary metabolites in P. kingianum Coll.et Hemsl., offering valuable information for the sustainable utilization and enhancement of this plant species.

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“…Polygonatum, a widely recognized medicinal and edible plant, has been demonstrated to possess various biological activities and a potentially significant market status [41,42].…”

Section: Discussionmentioning

confidence: 99%

Combined Metabolomics and Transcriptomics Analysis of the Distribution of Flavonoids in the Fibrous Root and Taproot of Polygonatum kingianum Coll.et Hemsl

Mo,

Wang,

et al. 2024

Genes

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“…55 The relationship between the biological activity and the chemical structure of a polysaccharide is based on both the primary structure and the higher structure, and there are still many difficulties in the analysis of the high-level spatial structure of polysaccharides. 56,57 Therefore, the degradation of polysaccharides into AP/OFs to study the active centres of polysaccharides avoids the analysis of highly complex polysaccharide structures, thus making it possible to study the structure-effect relationships between the AP/OFs and the target proteins. However, there are several technical challenges in testing the above scientific hypotheses: (1) the establishment of a targeted and controlled degradation method for polysaccharides to ensure the acquisition of structurally consistent polysaccharide active centres and (2) the performance of the advanced structural analysis of active fragments ( polysaccharide or oligosaccharide).…”

Section: Reviewmentioning

confidence: 99%

Structure–effect relationship studies of polysaccharides based on receptor–active centres: an alternative view

Zhang

Bai

et al. 2023

Food Funct.

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Effects of different extraction methods on the structural characterization and bioactivities of polysaccharides extracted from Polygonatum sibiricum

Yang,

Zhou,

Yang

et al. 2023

Food Measure

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Recent advances in polysaccharides from the genus Polygonatum: Isolation, structures, bioactivities, and application

Cited by 15 publications

References 63 publications

Combined Metabolomics and Transcriptomics Analysis of the Distribution of Flavonoids in the Fibrous Root and Taproot of Polygonatum kingianum Coll.et Hemsl

Combined Metabolomics and Transcriptomics Analysis of the Distribution of Flavonoids in the Fibrous Root and Taproot of Polygonatum kingianum Coll.et Hemsl

Structure–effect relationship studies of polysaccharides based on receptor–active centres: an alternative view

Effects of different extraction methods on the structural characterization and bioactivities of polysaccharides extracted from Polygonatum sibiricum

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