Recent advances in polyhydroxyalkanoate production by bacterial fermentation: mini-review

Lee, Sang Yup; Choi, Jong-il; Wong, Heng Ho

doi:10.1016/s0141-8130(99)00012-4

Cited by 167 publications

(85 citation statements)

References 37 publications

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“…Moreover, PHAs are also used to produce fiber materials, such as non-woven fabrics (7). The PHAs are considered as a source for the synthesis of chiral compounds (enantiometrically pure chemicals) and are raw materials for the production of paints (31,32,264). In addition to its range of material properties and resulting applications, PHAs promise to be a new source of small molecules.…”

Section: (4) Miscellaneous Applicationsmentioning

confidence: 99%

“…A hydrolysis step is commonly needed before inoculation with pure cultures (279,280). However, so far, only low PHB content and productivity were achieved from waste products (264). Since, the harsh conditions like nutrient limitation and stress are necessary to trigger PHA production and intracellular accumulation, therefore, environmental parameters such as pH and temperature have significant effects on microbial growth and PHA production (281).…”

Section: Economical Aspectsmentioning

confidence: 99%

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Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Muhammadi

Shabina

Afzal

et al. 2015

Green Chemistry Letters and Reviews

270

139

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Polyhydroxyalkanoates (PHAs) are intracellular aliphatic polyesters synthesized as energy reserves, in the form of water-insoluble, nano-sized discrete and optically dense granules in cytoplasm by a diverse bacteria and some archae under conditions of limiting nutrients in the presence of excess carbon source. Bacteria synthesize different PHAs from coenzyme A thioesters of respective hydroxyalkanoic acid, and degrade intracellularly for reuse and extracellularly in natural environments by other microorganisms. In vivo, PHAs exist as amorphous mobile liquid and water-insoluble inclusions but in vitro, exhibit material and mechanical properties, ranging from stiff and brittle crystalline to elastomeric and molding, similar to petrochemical thermoplastics. Further, they are hydrophobic, isotactic, biocompatible and exhibit piezoelectric properties. But as commodity plastics their applications are limited by high production cost, low yield, in vivo degradation, complexity of technology and difficulty of extraction. Therefore, to replace the conventional plastic with PHAs, it is prerequisite to standardize the PHA production systems.

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Section: (4) Miscellaneous Applicationsmentioning

confidence: 99%

Section: Economical Aspectsmentioning

confidence: 99%

Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Muhammadi

Shabina

Afzal

et al. 2015

Green Chemistry Letters and Reviews

270

139

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“…More than 300 different microorganisms are known to synthesize and accumulate PHA (Lee et al 1999), and almost 500 PHA degraders (bacteria and molds) have been isolated from different environments (Mergaert and Swings 1996). Most of them are soil bacteria and molds.…”

Section: ~20~----------------------~mentioning

confidence: 99%

Effects of glucose and glycine on the biodegradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB / V) and the proliferation of PHB / V-degrading microorganisms in soil suspension

Song

Wang

Ono

et al. 2002

Soil Science and Plant Nutrition

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“…Biodegradable polymers are defined as materials whose physical and chemical properties undergo decline and completely mortify when exposed to microbes, carbon dioxide (aerobic) processes, methane (anaerobic processes), and water (aerobic and anaerobic processes). [1] Bio-based polymers can be biodegradable or nondegradable. Similarly, while many bio-based polymers are biodegradable, not all biodegradable polymers are biobased.…”

mentioning

confidence: 99%

“…These biodegradable plastic materials can retain the desired material properties of conformist synthetic plastics and can be completely degraded without parting any undesirable rest. [1,2] With the aim of substituting the functionality of plastics of the petrochemical source, as well as mounting the range of application of bioplastics to an extensive range, polyhydroxyalkanoates (PHAs) are supposed as the most suitable materials because of their adaptability in terms of physical properties and chemical characteristics. [2] Polyhydroxybutyrate (PHB) is the most widely studied member of the PHA family and the first one that has been produced at industrialized scale.…”

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confidence: 99%

Untitled

Payghan

2016

IJGP

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Objective: There has been considerable interest in the development of biodegradable polymers such as poly-β-hydroxybutyrate (PHB) from bacterial origin which could help in solving probable problems due to the use of synthetic polymers. Many synthetic polymers are being used now-a-days in drug delivery systems. However, synthetic polymers have certain disadvantages such as their nonbiodegradability and so probability of bioaccumulation. Such accumulations for long time in body are harmful. This explains a need of easily biodegradable and a biocompatible polymer. Bacteria can synthesize a wide range of biopolymers which are biodegradable, biocompatible and have material properties suitable for medical applications. Bacterial polymers such as PHB are found to be functionally more effective and can be better for use in the pharmaceutical field. Materials and Methods: These studies started with screening of better producer of PHB from soil. This study represents a work on screening of bacterial isolates capable of producing PHB, and production of PHB using laboratory scale fermentation procedures. Using nutrient agar, we could screen four bacteria from soil, capable of producing PHB, using Sudan black-B staining. We also used a pure bacterial culture of Alcaligenes latus obtained from Microbial Type Culture Collection Chandigarh as a producer of PHB. Results: Out of these five bacterial isolates, A. latus found to produce PHB in relatively more amounts yielding about 55%. We used A. latus for production of PHB in large quantity. The morphological tests, physiochemical assessment, and characterizations of finished polymer were carried out. PHB shows viscosity 0.7993 (Pa.s), sharp peak arouse at 176.12°C in differential scanning calorimetry analysis, 235.8 nm λmax, successive Fourier transform infrared analysis, energy dispersive X-ray spectroscopy, and microscopic imaging analysis (scanning electron microscope [SEM]) were performed to get satisfactory reasoning for confirmation. Conclusion: PHB was used for formulating various formulations and was found to give good results, hence was concluded to be a better polymer in the pharmaceutical field.

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Recent advances in polyhydroxyalkanoate production by bacterial fermentation: mini-review

Cited by 167 publications

References 37 publications

Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Effects of glucose and glycine on the biodegradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB / V) and the proliferation of PHB / V-degrading microorganisms in soil suspension

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