Recent advances in poly(ionic liquid)s for biomedical application

Liu, Chunxia; Raza, Faisal; Qian, Hai; Tian, Xin

doi:10.1039/d2bm00046f

Cited by 14 publications

(10 citation statements)

References 201 publications

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“…[90] ILs have good bacteriostatic effects, especially imidazoles, [147] piperazines, guanidino-, [148] pyrrolidinyl- [149] IL monomers, and polyionic liquids. [150] Their association with antibacterial drugs has synergistic effects. [151][152][153][154] ILs not only have a synergistic effect with antibacterial drugs but also have a strong bactericiadal effect.…”

Section: Ionic Liquid-peptides and Ionic Liquid-proteinsmentioning

confidence: 99%

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Tai

et al. 2023

Advanced Therapeutics

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Transdermal drug delivery is a promising strategy characterized by minor fluctuations in blood concentrations, few adverse effects, convenience, and excellent patient compliance, especially for biomacromolecules. Conversely, traditional delivery methods are limited by their poor penetration abilities and complex preparation and application techniques. However, some inherent properties of biomacromolecules, such as large sizes, complex structure, and poor stability, can affect their ability to overcome skin barriers and reach deeper layers. Ionic liquids (ILs) are organic salts composed of asymmetric cations and anions in liquid form below 100 °C. ILs provide excellent protection for biomacromolecules and can facilitate their passage through the stratum corneum to cells for therapeutic effects. Therefore, they represent one of the most promising approaches to promoting transdermal penetration. Here, the barriers to effective transdermal delivery, including skin properties and the stability and biocompatibility of IL‐based biomacromolecule formulations, are highlighted and the current status of IL‐based biomacromolecule formulations are focused on, the tremendous advantages of using ILs based on current challenges in transdermal drug delivery are discussed, and light is shed on several ILs frequently used in the delivery of biomacromolecules.

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Section: Ionic Liquid-peptides and Ionic Liquid-proteinsmentioning

confidence: 99%

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Tai

et al. 2023

Advanced Therapeutics

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“…PILs are polymers containing ions in their side-chain or backbone, which have specific characteristics, e.g., negligible vapor pressure, stable physical and chemical properties, and self-assembly capabilities, etc. 16,17 PILs are most commonly obtained with two or more ionic liquid monomers (ILMs), by adopting two approaches for their synthesis. One is to preferentially synthesize two ILMs through ion exchange, followed by the addition of an initiator to prepare PILs; another is that the copolymer is first prepared and its anionic or cationic moieties are then replaced in an ion exchange to synthesize the PILs.…”

Section: Preparations Characteristics and Applications Of Il-based Na...mentioning

confidence: 99%

Advances of ionic liquid-based nanohybrids for biomedical applications

Gao

Xue

et al. 2023

J. Mater. Chem. B

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“…27 Based on these unique physicochemical properties, PIL−polymer composites have been widely used in many fields including sensors, energy storage materials, biomedicine, eco-materials, etc. 28,29 Meanwhile, research on the preparation method and functional improvement of PIL hydrogels has also been quietly carried out. 30−33 Compared with the hydrogel prepared with ionic liquid (IL) as a solvent, the preparation of hydrogels through in situ polymerization of IL monomers has more advantages.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, polymeric ionic liquids (PILs) have garnered tremendous attention due to their high conductivity, chemical stability, structural designability, antibacterial activity, and biocompatibility . Based on these unique physicochemical properties, PIL–polymer composites have been widely used in many fields including sensors, energy storage materials, biomedicine, eco-materials, etc. , Meanwhile, research on the preparation method and functional improvement of PIL hydrogels has also been quietly carried out. − Compared with the hydrogel prepared with ionic liquid (IL) as a solvent, the preparation of hydrogels through in situ polymerization of IL monomers has more advantages. It avoids the leakage of conventional ionic liquid-impregnated polymer hydrogel caused by deformation and retains the unique properties of PILs.…”

Section: Introductionmentioning

confidence: 99%

Novel Uracil-Functionalized Poly(ionic liquid) Hydrogel: Highly Stretchable and Sensitive as a Direct Wearable Ionic Skin for Human Motion Detection

Huang

Xie

et al. 2023

ACS Appl. Mater. Interfaces

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Conductive hydrogel-based ionic skins have attracted immense attention due to their great application prospects in wearable electronic devices. However, simultaneously achieving a combination of a single hydrogel system and excellent comprehensive performance (i.e., mechanical durability, electrical sensitivity, broad-spectrum antibacterial activity, and biocompatibility) remains a challenge. Thus, a novel poly(ionic liquid) hydrogel consisting of poly(acrylamide-co-lauryl methacrylate-co-methyl-uracil-imidazolium chloride-co-2-acryloylamino-2-methyl-1-propane sulfonic acid) (AAm-LMA-MUI-AMPS) was prepared by a micellar copolymerization method. Herein, MUI serves as a supramolecular crosslinker and conductive and bacteriostatic components. Owing to the multiple supramolecular crosslinks and hydrophobic association in the network, the hydrogel exhibits excellent mechanical properties (624 kPa of breaking stress and 1243 kPa of compression stress), skin-like modulus (46.2 kPa), stretchability (1803%), and mechanical durability (200 cycles under 500% strain can be completely recovered). Moreover, with the coordinated combination of each monomer, the hydrogel exhibits the unique advantage of high conductivity (up to 59.34 mS/cm). Hence, the hydrogel was further assembled as an ionic skin sensor, which exhibited a gauge factor (GF) of 10.74 and 7.27 with and without LiCl over a broad strain range (1–1000%), respectively. Furthermore, the hydrogel sensor could monitor human movement in different strain ranges, including body movement and vocal cord vibration. In addition, the antibacterial activity and biocompatibility of the hydrogel sensor were investigated. These findings present a new strategy for the design of new-generation wearable devices with multiple functions.

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Recent advances in poly(ionic liquid)s for biomedical application

Abstract: Poly(ionic liquid)s (PILs) are polymers containing ions in their side-chain or backbone, the designability and outstanding physicochemical properties of PILs have attracted widespread attention from researchers. PILs own the specific...

Cited by 14 publications

References 201 publications

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Advances of ionic liquid-based nanohybrids for biomedical applications

Novel Uracil-Functionalized Poly(ionic liquid) Hydrogel: Highly Stretchable and Sensitive as a Direct Wearable Ionic Skin for Human Motion Detection

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