Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity

Liu, Silin; Fang, Chongkai; Zhong, Chong; Li, Jing; Xiao, Qingzhong

doi:10.1007/s10565-023-09835-4

Cited by 3 publications

(2 citation statements)

References 125 publications

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“… HiPSC-derived hepatocytes [ 51 , 52 ]. HiPSC-derived cardiac myocytes [ 53 , 54 ]. HiPSC-Derived gastric cells [ 55 ].…”

Section: Physiological Relevance Of 3d Cell Cultures To the Ecmmentioning

confidence: 99%

Scaffold-based 3D cell culture models in cancer research

Abuwatfa,

Pitt,

Husseini

2024

J Biomed Sci

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Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions between cancer cells and their surrounding stroma. Tumors consist not only of cancer cells but also various other cell types, including stromal cells, immune cells, and blood vessels. These models bridge traditional 2D cell cultures and animal models, offering a cost-effective, scalable, and ethical alternative for preclinical research. As the field advances, 3D cell cultures are poised to play a pivotal role in understanding cancer biology and accelerating the development of effective anticancer therapies. This review article highlights the key advantages of 3D cell cultures, progress in the most common scaffold-based culturing techniques, pertinent literature on their applications in cancer research, and the ongoing challenges. Graphical Abstract

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“… HiPSC-derived hepatocytes [ 51 , 52 ]. HiPSC-derived cardiac myocytes [ 53 , 54 ]. HiPSC-Derived gastric cells [ 55 ].…”

Section: Physiological Relevance Of 3d Cell Cultures To the Ecmmentioning

confidence: 99%

Scaffold-based 3D cell culture models in cancer research

Abuwatfa,

Pitt,

Husseini

2024

J Biomed Sci

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“…Another study accurately characterizes cardiotoxic damage caused by the anticancer drug doxorubicin through self-assembled cardiac organoids [ 164 ]. It has recently been found that hiPSC-CMs can be used to simulate antitumor drug-induced cardiotoxicity in vitro [ 165 ], which may provide more recommendations for future use of antitumor drugs. For example, the chemotherapy drug mitoxantrone can cause arrhythmias, and studies in cardiac organoids have found that co-administration of metformin can partially reverse this effect [ 166 ].…”

Section: Application Of Cardiovascular Organoidsmentioning

confidence: 99%

Progress of organoid platform in cardiovascular research

Du,

Jia,

Chang

et al. 2024

Bioactive Materials

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Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

Clancy,

Santana

2024

The Journal of Physiology

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A transformation is underway in precision and patient‐specific medicine. Rapid progress has been enabled by multiple new technologies including induced pluripotent stem cell‐derived cardiac myocytes (iPSC‐CMs). Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of differentiation into the cardiac lineage, the functional characterization of the resulting cardiac myocytes, and the many applications of in silico models to understand general and patient‐specific mechanisms controlling excitation–contraction coupling in health and disease. Furthermore, we explore the current and potential applications of iPSC‐CMs in both research and clinical settings, underscoring the far‐reaching implications of this rapidly evolving field. image

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Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity

Cited by 3 publications

References 125 publications

Scaffold-based 3D cell culture models in cancer research

Scaffold-based 3D cell culture models in cancer research

Progress of organoid platform in cardiovascular research

Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

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