Recent advances in peptide-based therapeutic strategies for breast cancer treatment

Abstract

Breast cancer is the leading cause of cancer-related fatalities in female worldwide. Effective therapies with low side effects for breast cancer treatment and prevention are, accordingly, urgently required. Targeting anticancer materials, breast cancer vaccines and anticancer drugs have been studied for many years to decrease side effects, prevent breast cancer and suppress tumors, respectively. There are abundant evidences to demonstrate that peptide-based therapeutic strategies, coupling of good safety and adaptive functionalities are promising for breast cancer therapy. In recent years, peptide-based vectors have been paid attention in targeting breast cancer due to their specific binding to corresponding receptors overexpressed in cell. To overcome the low internalization, cell penetrating peptides (CPPs) could be selected to increase the penetration due to the electrostatic and hydrophobic interactions between CPPs and cell membranes. Peptide-based vaccines are at the forefront of medical development and presently, 13 types of main peptide vaccines for breast cancer are being studied on phase III, phase II, phase I/II and phase I clinical trials. In addition, peptide-based vaccines including delivery vectors and adjuvants have been implemented. Many peptides have recently been used in clinical treatments for breast cancer. These peptides show different anticancer mechanisms and some novel peptides could reverse the resistance of breast cancer to susceptibility. In this review, we will focus on current studies of peptide-based targeting vectors, CPPs, peptide-based vaccines and anticancer peptides for breast cancer therapy and prevention.

Self-assembly of hydrazide-linked porous organic polymers rich in titanium for efficient enrichment of glycopeptides and phosphopeptides from human serum

“…The leading cause of cancer deaths in women is breast cancer. 30 The serum of breast cancer patients, a typical clinical bio-sample, is frequently used to deliver valuable information regarding the dynamic evolution of the human organism. Intensive investigation of glycopeptides and phosphopeptides in breast cancer serum may provide valuable details for incipient prediction and pathogenesis of breast cancer.…”

Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies

“…Their ndings demonstrated that these nanoparticles signicantly improved therapy efficacy, particularly in breast cancer cases with overexpression of EGFR. 105,106 4.5.3. RNA-based therapeutics.…”

Examining the functional space of gut microbiome‐derived peptides

“…These peptides have been found in various environments, not just the gut microbiome, and serve as inspiration for gut peptide discovery efforts. Various reviews have shown how ACPs can be effective against different tumors and cancer cells (Jafari et al, 2022;Karami Fath et al, 2022;Li et al, 2023).…”

“…These peptides have been found in various environments, not just the gut microbiome, and serve as inspiration for gut peptide discovery efforts. Various reviews have shown how ACPs can be effective against different tumors and cancer cells (Jafari et al, 2022 ; Karami Fath et al, 2022 ; Li et al, 2023 ). In addition to direct inhibition of cancer cells, ACPs can also have an immunomodulatory effect as demonstrated in mouse models (Çuburu, 2022 ).…”