Recent advances in organoid engineering: A comprehensive review

Unagolla, Janitha M.; Jayasuriya, Ambalangodage C.

doi:10.1016/j.apmt.2022.101582

Cited by 27 publications

(31 citation statements)

References 201 publications

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“…[ 47,48 ] As a printing method, SLB boasts good accuracy, fast fabrication speeds, and high cell viability (>85 % viability). [ 49–51 ] However, this method often leaves residual photo‐initiators, such as Irgacure 2959, Irgacure 184, and Irgacure 651. [ 47 ] Furthermore, the harmful effects of UV light on cells, which is common in stereolithography, cannot be ignored.…”

Section: Simulating the Matrix Components For Biofabrication: Bioprin...mentioning

confidence: 99%

Advances in 3D Bioprinting for Cancer Biology and Precision Medicine: From Matrix Design to Application

Jung

Ghamrawi

et al. 2022

Adv Healthcare Materials

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The tumor microenvironment is highly complex owing to its heterogeneous composition and dynamic nature. This makes tumors difficult to replicate using traditional 2D cell culture models that are frequently used for studying tumor biology and drug screening. This often leads to poor translation of results between in vitro and in vivo and is reflected in the extremely low success rates of new candidate drugs delivered to the clinic. Therefore, there has been intense interest in developing 3D tumor models in the laboratory that are representative of the in vivo tumor microenvironment and patient samples. 3D bioprinting is an emerging technology that enables the biofabrication of structures with the virtue of providing accurate control over distribution of cells, biological molecules, and matrix scaffolding. This technology has the potential to bridge the gap between in vitro and in vivo by closely recapitulating the tumor microenvironment. Here, a brief overview of the tumor microenvironment is provided and key considerations in biofabrication of tumor models are discussed. Bioprinting techniques and choice of bioinks for both natural and synthetic polymers are also outlined. Lastly, current bioprinted tumor models are reviewed and the perspectives of how clinical applications can greatly benefit from 3D bioprinting technologies are offered.

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Section: Simulating the Matrix Components For Biofabrication: Bioprin...mentioning

confidence: 99%

Advances in 3D Bioprinting for Cancer Biology and Precision Medicine: From Matrix Design to Application

Jung

Ghamrawi

et al. 2022

Adv Healthcare Materials

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“…[ 70,71 ] In recent years, as the technique matures, a growing number of 3D printing approaches have emerged based on inkjet, laser, extrusion, melt electrowriting (MEW), etc., through which a high degree of automation of soft films with actuating capabilities could be fabricated. [ 48–56 ] Inkjet printing is a programmed process of depositing ink droplets on the substrate controlled by computers, suitable for the fabrication of responsible hydrogel actuators which are polymerized by UV light. [ 57 ] Laser‐based 3D printing uses laser powers to discharge and transfer inkjet droplets from the donor layers onto the substrates.…”

Section: Fabrication Of the Sfasmentioning

confidence: 99%

Smart Film Actuators for Biomedical Applications

Zhang

Wang

Qiao

et al. 2022

Small

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Taking inspiration from the extremely flexible motion abilities in natural organisms, soft actuators have emerged in the past few decades. Particularly, smart film actuators (SFAs) demonstrate unique superiority in easy fabrication, tailorable geometric configurations, and programmable 3D deformations. Thus, they are promising in many biomedical applications, such as soft robotics, tissue engineering, delivery system, and organ‐on‐a‐chip. In this review, the latest achievements of SFAs applied in biomedical fields are summarized. The authors start by introducing the fabrication techniques of SFAs, then shift to the topology design of SFAs, followed by their material selections and distinct actuating mechanisms. After that, their biomedical applications are categorized in practical aspects. The challenges and prospects of this field are finally discussed. The authors believe that this review can boost the development of soft robotics, biomimetics, and human healthcare.

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“…[ 44 ] Layer‐by‐layer assembly, 3D printing, inkjet printing, fused deposition modeling, stereolithography, microfluidic fabrication strategies have been widely applied for preparing hydrogel nanostructures. [ 45–48 ] Nevertheless, all fabrication processes fail to maximize hydrogels’ potential for biosensing purposes. Hence, it is important to sort out which tethering process is suitable for biosensing.…”

Section: Nanoarchitectured Hydrogel For Biosensingmentioning

confidence: 99%

Hydrogel Nanoarchitectonics: An Evolving Paradigm for Ultrasensitive Biosensing

Nishat

Hossain

Islam

et al. 2022

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The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure‐integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next‐generation robust biosensors.

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Recent advances in organoid engineering: A comprehensive review

Cited by 27 publications

References 201 publications

Advances in 3D Bioprinting for Cancer Biology and Precision Medicine: From Matrix Design to Application

Advances in 3D Bioprinting for Cancer Biology and Precision Medicine: From Matrix Design to Application

Smart Film Actuators for Biomedical Applications

Hydrogel Nanoarchitectonics: An Evolving Paradigm for Ultrasensitive Biosensing

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