Recent advances in optical coherence tomography for the diagnoses of lung disorders

Hou, Randy; Le, Tho Huu; Murgu, Septimiu; Chen, Zhongping; Brenner, Mary E.

doi:10.1586/ers.11.59

Cited by 40 publications

(20 citation statements)

References 60 publications

(66 reference statements)

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“…The technology has also found uses in pulmonary medicine, cardiology, gastroenterology, neurology, and surgery, with emerging applications in many other fields [2, 3, 4, 5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

2012

Case Rep Dermatol

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Optical coherence tomography (OCT) is an imaging technology with the potential to provide high-resolution images of the skin non-invasively. With this device, it is possible to identify a host of skin structures including tumors. In this case report, we demonstrate the use of an OCT device in delineating a lateral tumor margin of an ill-defined basal cell carcinoma prior to Mohs micrographic surgery. Following surgery, the OCT images are compared to histologic sections to confirm their accuracy. OCT technology has the potential to be a vital tool for dermatologists and particularly Mohs surgeons in identifying tumor margins and potentially reducing the number of invasive procedures needed.

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“…The technology has also found uses in pulmonary medicine, cardiology, gastroenterology, neurology, and surgery, with emerging applications in many other fields [2, 3, 4, 5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

2012

Case Rep Dermatol

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“…OCT can be used to conduct large-volume in vivo microscopy of tissue with resolutions comparable to low-power microscopy (18). OCT has been used to accurately detect and diagnose pathology in vivo for a number of years (17)(18)(19)(20)(21)(22)(23)(24) and has been used to assess the fine microarchitectural features in both normal and pathologic lung (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43).…”

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.Objectives: We aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.Methods: A total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology. Measurements and Main Results:The average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively. Conclusions:Although these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.

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“…OCT, for instance, allows real-time, near-microscopic resolution imaging of the muco-sal and submucosal airway wall during bronchoscopy. 58 In a feasibility study, OCT has been used to assess response to BT. 59 Radial probe balloon-based endobronchial ultrasound is a readily available technology that has successfully been used to measure airway wall thickness in patients with asthma and also might be useful in selecting patients for BT and monitoring treatment response.…”

Section: Bronchoscopic Treatment Of Asthmamentioning

confidence: 99%

Interventional Pulmonology for Asthma and Emphysema: Bronchial Thermoplasty and Bronchoscopic Lung Volume Reduction

Miller

Murgu

2014

Semin Respir Crit Care Med

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Emphysema and asthma are responsible for economic and social burden. Altering the natural course of these diseases is a field of intense research. The National Emphysema Treatment Trial showed that lung volume reduction surgery (LVRS) could significantly reduce both morbidity and mortality in properly selected patients. LVRS is seldom performed, however, due to the high morbidity associated with the surgery. Numerous bronchoscopic interventions have been introduced with the goal of providing the clinical benefits of LVRS without the surgical complications. Thus far, these modalities have not produced the results once hoped. However, through active modification of both technique and patient selection, the role of minimally invasive modalities in the treatment of emphysema continues to evolve. Bronchial thermoplasty (BT) is a method of delivering controlled heat to airway mucosa with the goal of reducing airway smooth muscle mass and hence bronchoconstriction. In patients suffering from asthma who cannot achieve control with standard medical care, BT has been shown to be safe and improves symptoms, with long lasting benefit. BT does not seem to affect traditional markers of asthma severity such as forced expiratory volume in 1 second and questions remain regarding proper patient selection for this therapy and its true physiologic effects. This article is a review of bronchoscopic modalities for emphysema and asthma.

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Recent advances in optical coherence tomography for the diagnoses of lung disorders

Cited by 40 publications

References 60 publications

Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Interventional Pulmonology for Asthma and Emphysema: Bronchial Thermoplasty and Bronchoscopic Lung Volume Reduction

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