Recent advances in optical aptasensor technology for amplification strategies in cancer diagnostics

Kou, Xinyue; Zhang, Xujia; Shao, Xuejun; Jiang, Chenyu; Ning, Limin

doi:10.1007/s00216-020-02774-7

Cited by 24 publications

(17 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A phenomenon where emitted light from a substance is not because of heat is called luminescence, which can be categorized based on the energy (trigger) sources into electrochemiluminescence (ECL) and chemiluminescence (CL). Both are widely used in the development of aptasensors employed in cancer biomarkers detection (56). Several CL aptasensors for early cancer detection have already been introduced (57).…”

Section: Chemiluminescence Based Optical Aptasensorsmentioning

confidence: 99%

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Zahra

Khan

2021

Front. Oncol.

View full text Add to dashboard Cite

Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) have recently shown promising results in terms of sensitivity, identification, or detection of either cancerous cells or the associated biomarkers. In this mini-review, we have summarized the most recent (2016–2020) developments in different approaches belonging to optical aptasensor technologies being widely employed for their simple operation, sensitivity, and early cancer diagnostics. Finally, we shed some light on limitations, advantages, and current challenges of aptasensors in clinical diagnostics, and we elaborated on some future perspectives.

show abstract

Section: Chemiluminescence Based Optical Aptasensorsmentioning

confidence: 99%

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Zahra

Khan

2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…As we mentioned above, a huge variety of aptasensing platforms have been developed to the moment for the detection of analytes related to food safety [35,36], environmental studies [37][38][39], and clinical diagnostics [19,40,41]. Most of them rely on optical (colorimetrical, fluorescent, luminescent, or surface plasmon resonance (SPR)) [9,10,39] and electrochemical (current, conductance, potential, and impedance) [42,43] types of the analytical signal.…”

Section: Aptasensors-aptamer-based Bioanalytical Systemsmentioning

confidence: 99%

“…Outside of clinical trials, antibodies are rarely characterized and On the other hand, aptamers recognizing biomarkers serve as biospecific elements for diagnostic systems. Relatively small molecular size, huge possibilities of chemical modification, and compatibility with various biosensing platforms have brought to life an enormous repertoire of aptamer-based detection systems, from fast and straightforward point-of-care assays to sophisticated schemes and devices [8][9][10][11]. Aptamer-based detection systems are now on the way to clinical applications, with several examples of commercial aptamer-based assays [12,13].…”

Section: Introductionmentioning

confidence: 99%

Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications

et al. 2020

View full text Add to dashboard Cite

Nucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers’ research and development for biomedicine is made on cardiovascular, infectious, and malignant diseases, the use of aptamers as therapeutic or diagnostic tools in the context of rheumatic diseases is no less important. In this review, we consider the main features of aptamers that make them valuable molecular tools for rheumatologists, and summarize the studies on the selection and application of aptamers for protein biomarkers associated with rheumatic diseases. We discuss the progress in the development of aptamer-based diagnostic assays and targeted therapeutics for rheumatic disorders, future prospects in the field, and issues that have yet to be addressed.

show abstract

“…Aptamers are successfully applied for the determination of proteins [17,18], drugs [19,20], cancer biomarkers [21][22][23], living cells (pathogenic bacteria, circulating cancer cells) [24][25][26], etc. For monitoring of the aptamer-analyte interactions, various optical techniques have been used, mostly derived from fluorescence [27,28] and absorbance [29][30][31] spectroscopy. Meanwhile, electrochemical transduces remain the most frequently applied in the assembly of aptasensors due to the obvious advantages they possess [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Aptasensors Based on Hybrid Metal-Organic Frameworks

Evtugyn

Belyakova

Porfireva

et al. 2020

Sensors

View full text Add to dashboard Cite

Metal-organic frameworks (MOFs) offer a unique variety of properties and morphology of the structure that make it possible to extend the performance of existing and design new electrochemical biosensors. High porosity, variable size and morphology, compatibility with common components of electrochemical sensors, and easy combination with bioreceptors make MOFs very attractive for application in the assembly of electrochemical aptasensors. In this review, the progress in the synthesis and application of the MOFs in electrochemical aptasensors are considered with an emphasis on the role of the MOF materials in aptamer immobilization and signal generation. The literature information of the use of MOFs in electrochemical aptasensors is classified in accordance with the nature and role of MOFs and a signal mode. In conclusion, future trends in the application of MOFs in electrochemical aptasensors are briefly discussed.

show abstract

Recent advances in optical aptasensor technology for amplification strategies in cancer diagnostics

Cited by 24 publications

References 119 publications

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications

Electrochemical Aptasensors Based on Hybrid Metal-Organic Frameworks

Contact Info

Product

Resources

About