Recent Advances in Ocular Drug Delivery Systems

Nayak, Smita; Jadhav, Madhuri; Bhaskar, V. H.

doi:10.5958/0974-360x.2016.00189.x

“…In order to avoid jeopardizing lens parameters (transmittance, permeability to oxygen and water content) said nanogel is dispersed in the p-HEMA metric that makes up the lens. 32…”

Section: Manufacturing Strategies For Drug-carrying Contact Lensesmentioning

confidence: 99%

Contact lenses as drug-delivery systems: a promising therapeutic tool

Holgado

¹

,

Anguiano-Domínguez

²

,

Martín-Banderas

³

2020

Archivos de la Sociedad Española de Oftalmología (English Editi

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The ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical technology, attempts have been made to use various solutions in order to increase bioavailability in the most common pharmaceutical forms, it has not been entirely satisfactory. In this context, contact lenses are presented as drug delivery systems that largely remedy these two major problems and offer other additional advantages. Therefore, the use of contact lenses as drug carrying systems has been increasingly investigated in recent years, as they can increase the bioavailability of these drugs, leading to an increase in therapeutic efficacy and compliance.The main techniques used to achieve this goal are included in this review, including immersion in drug solutions, use of vitamin E barriers, molecular printing, colloidal systems, etc. The most interesting results, depending on the different eye pathologies, are presented.Although the use of contact lenses as a vehicle for the release of active ingredients is a relatively novel strategy, there are already many studies and trials that support it. In any case, further research needs to be carried out to finally reach an effective, safe, and stable product that can be marketed.

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Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions

Lalu

¹

,

Tambe

²

,

Pradhan

³

et al. 2017

Journal of Controlled Release

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Lentes de contacto para vehiculizar principios activos: una prometedora herramienta terapéutica

Holgado

¹

,

Anguiano-Domínguez

²

,

Martín-Banderas

³

2020

Archivos de la Sociedad Española de Oftalmología

View full text Add to dashboard Cite

The ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical technology, attempts have been made to use various solutions in order to increase bioavailability in the most common pharmaceutical forms, it has not been entirely satisfactory. In this context, contact lenses are presented as drug delivery systems that largely remedy these two major problems and offer other additional advantages. Therefore, the use of contact lenses as drug carrying systems has been increasingly investigated in recent years, as they can increase the bioavailability of these drugs, leading to an increase in therapeutic efficacy and compliance.The main techniques used to achieve this goal are included in this review, including immersion in drug solutions, use of vitamin E barriers, molecular printing, colloidal systems, etc. The most interesting results, depending on the different eye pathologies, are presented.Although the use of contact lenses as a vehicle for the release of active ingredients is a relatively novel strategy, there are already many studies and trials that support it. In any case, further research needs to be carried out to finally reach an effective, safe, and stable product that can be marketed.

show abstract

Recent Advances in Ocular Drug Delivery Systems

Cited by 9 publications

References 0 publications

Contact lenses as drug-delivery systems: a promising therapeutic tool

Contact lenses as drug-delivery systems: a promising therapeutic tool

Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions

Lentes de contacto para vehiculizar principios activos: una prometedora herramienta terapéutica

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