Recent Advances in Nutraceuticals and Functional Foods

Lau, Francis C.; Bagchi, Debasis; Zafra-Stone, Shirley; Bagchi, Manashi

doi:10.1002/9780813821474.ch1

Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods 2010

DOI: 10.1002/9780813821474.ch1

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Recent Advances in Nutraceuticals and Functional Foods

Francis C. Lau¹,

Debasis Bagchi

Shirley Zafra-Stone

et al.

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Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

Kumar

Mosa

et al. 2017

Critical Reviews in Food Science and Nutrition

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Today, the dramatic changes in types of food consumed have led to an increased burden of chronic diseases. Therefore, the emphasis of food research is not only to ensure quality food that can supply adequate nutrients to prevent nutrition related diseases, but also to ensure overall physical and mental-health. This has led to the concept of functional foods and nutraceuticals (FFNs), which can be ideally produced and delivered through plants. Metabolomics can help in getting the most relevant functional information, and thus has been considered the greatest -OMICS technology to date. However, metabolomics has not been exploited to the best potential in plant sciences. The technology can be leveraged to identify the health promoting compounds and metabolites that can be used for the development of FFNs. This article reviews (i) plant-based FFNs-related metabolites and their health benefits; (ii) use of different analytic platforms for targeted and non-targeted metabolite profiling along with experimental considerations; (iii) exploitation of metabolomics to develop FFNs in plants using various biotechnological tools; and (iv) potential use of metabolomics in plant breeding. We have also provided some insights into integration of metabolomics with latest genome editing tools for metabolic pathway regulation in plants.

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Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

Kumar

Mosa

et al. 2017

Critical Reviews in Food Science and Nutrition

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Phytochemicals targeting genes relevant for type 2 diabetes

Anuradha

2013

Can. J. Physiol. Pharmacol.

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Nutrigenomic approaches based on ethnopharmacology and phytotherapy concepts have revealed that type 2 diabetes mellitus (T2DM) may be susceptible to dietary intervention. Interaction between bioactive food components and the genome may influence cell processes and modulate the onset and progression of the disease. T2DM, characterized by insulin resistance and beta cell dysfunction, is one of the leading causes of death and disability. Despite the great advances that have been made in the understanding and management of this complex, multifactorial disease, T2DM has become a worldwide epidemic in the 21st century. Population and family studies have revealed a strong genetic component of T2DM, and a number of candidate genes have been identified in humans. Variations in the gene sequences such as single nucleotide polymorphisms, explain the individual differences in traits like disease susceptibility and response to treatment. A clear understanding of how nutrients affect the expression of genes should facilitate the development of individualized intervention and, eventually, treatment strategies for T2DM. Review of the literature identified many phytochemicals/extracts from traditional medicinal plants that can target diabetogenic genes. This review focuses on the genetic aspects of T2DM, nutrient modification of genes relevant for diabetes, and future prospects of nutritional therapy of T2DM.

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Recent Advances in Nutraceuticals and Functional Foods

Cited by 2 publications

References 36 publications

Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

Phytochemicals targeting genes relevant for type 2 diabetes

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