Recent advances in nonlinear optics for bio-imaging applications

Zhang, Silu; Liu, Liwei; Ren, Sheng; Li, Fulin; Zhao, Yihua; Yang, Zhigang; Hu, Rui; Qu, Junle

doi:10.29026/oea.2020.200003

Cited by 32 publications

(23 citation statements)

References 227 publications

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“…It was observed that cysteine, serine, arginine, ascorbic acid, dopamine, H 2 O 2 , and various other metal ions Opto-Electronic Advances 113 .…”

Section: Photoluminescence-based Sensorsmentioning

confidence: 99%

Light-emitting MXene quantum dots

Sharbirin¹,

Akhtar²,

Kim³

2021

OEA

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MXene (M n+1 X n ) is an emerging class of layered two-dimensional (2D) materials, which are derived from their bulk-state MAX phase (M n+1 AX n , where M: early transition metal, A: group element 13 and 14, and X: carbon and/or nitrogen). MXenes have found wide-ranging applications in energy storage devices, sensors, catalysis, etc. owing to their high electronic conductivity and wide range of optical absorption. However, the absence of semiconducting MXenes has limited their applications related to light emission. Research has shown that quantum dots (QDs) derived from MXene (MQDs) not only retain the properties of the parent MXene but also demonstrate significant improvement on light emission and quantum yield (QY). The optical properties and photoluminescence (PL) emission mechanisms of these light-emitting MQDs have not been comprehensively investigated. Recently, work on light-emitting MQDs has shown good progress, and MQDs exhibiting multi-color PL emission along with high QY have been fabricated. The synthesis methods also play a vital role in determining the light emission properties of these MQDs. This review provides an overview of light-emitting MQDs and their synthesis methods, optical properties, and applications in various optical, sensory, and imaging devices. The future prospects of light-emitting MQDs are also discussed to provide an insight that helps to further advance the progress on MQDs.

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“…It was observed that cysteine, serine, arginine, ascorbic acid, dopamine, H 2 O 2 , and various other metal ions Opto-Electronic Advances 113 .…”

Section: Photoluminescence-based Sensorsmentioning

confidence: 99%

Light-emitting MXene quantum dots

Sharbirin¹,

Akhtar²,

Kim³

2021

OEA

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“…In addition, CARS is derived from molecular vibration. Thus, it has chemical selectivity and chemical specificity [42]. Nonlinear optical techniques have been widely used to study biological samples because of their high optical spatial and temporal resolution, the absence of required additional labeling, nondestructive manipulation, and chemical specificity.…”

Section: Nonlinear Optical Microscopic Imagingmentioning

confidence: 99%

“…Nonlinear optical techniques have been widely used to study biological samples because of their high optical spatial and temporal resolution, the absence of required additional labeling, nondestructive manipulation, and chemical specificity. This part mainly introduces Aβ imaging by several nonlinear optical imaging techniques, including MPEF, SHG, THG, CARS, and SRS [42].…”

Section: Nonlinear Optical Microscopic Imagingmentioning

confidence: 99%

“…In recent years, nonlinear optical imaging technology has also been employed in the AD research field. In particular, it was applied to the detection of Aβ and tau aggregates, neurofibrillary tangles, and cerebral amyloid angiopathy; assessment of dendritic spines and accumulation of senile plaques; evaluation of the development of TPPP/p25 aggregates in patients with AD [42][43][44]. This review briefly introduces optical imaging methods and focuses on their application to Aβ plaque imaging (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease

Luo

Liu

et al. 2021

Biosensors

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Alzheimer’s disease (AD) is a multifactorial, irreversible, and incurable neurodegenerative disease. The main pathological feature of AD is the deposition of misfolded β-amyloid protein (Aβ) plaques in the brain. The abnormal accumulation of Aβ plaques leads to the loss of some neuron functions, further causing the neuron entanglement and the corresponding functional damage, which has a great impact on memory and cognitive functions. Hence, studying the accumulation mechanism of Aβ in the brain and its effect on other tissues is of great significance for the early diagnosis of AD. The current clinical studies of Aβ accumulation mainly rely on medical imaging techniques, which have some deficiencies in sensitivity and specificity. Optical imaging has recently become a research hotspot in the medical field and clinical applications, manifesting noninvasiveness, high sensitivity, absence of ionizing radiation, high contrast, and spatial resolution. Moreover, it is now emerging as a promising tool for the diagnosis and study of Aβ buildup. This review focuses on the application of the optical imaging technique for the determination of Aβ plaques in AD research. In addition, recent advances and key operational applications are discussed.

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“…Femtosecond laser direct writing has emerged as a new technique for advanced micro- and nano-manufacturing, which can fabricate structures with ultrahigh precision and flexible morphologies , that have various applications. − As an inherently 3D microfabrication technology, ,− femtosecond laser two-photon polymerization (TPP) has distinct advantages and has huge potential for the processing of innovative 3D micro- and nano-structures in biomedicine. With respect to the regulation of cell behavior, various types of biocompatible microstructures have been prepared via TPP microfabrication, such as freestanding proteinaceous spiral structures and polyhedral frameworks, nanogap plasmonic structures in microfluidic chips, 3D nanoporous architectures, nanostructured Brownian surfaces, and submicrometric patterned surfaces .…”

Section: Introductionmentioning

confidence: 99%

Density Regulation and Localization of Cell Clusters by Self-Assembled Femtosecond-Laser-Fabricated Micropillar Arrays

Wang

Yang

et al. 2021

ACS Appl. Mater. Interfaces

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Tumor cell clusters of varying sizes and densities have different metastatic potentials. Three-dimensional (3D) patterned structures with rational topographical and mechanical properties are capable of guiding the 3D clustering of tumor cells. In this study, single femtosecond laser pulses were used to fabricate individual high-aspectratio micropillars via two-photon polymerization (TPP). By combining this approach with capillary-force self-assembly, complex 3D microstructure patterns were constructed with a high efficiency. The microstructures were able to regulate the formation of cell clusters at different cell seeding densities and direct self-guided 3D assembly of cell clusters of various sizes and densities. Localization of cell clusters was achieved using grid-indexed samples to address individual cell clusters, which holds great promise for in situ cell cluster culture and monitoring and for applications such as RNA sequencing of cell clusters.

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Recent advances in nonlinear optics for bio-imaging applications

Cited by 32 publications

References 227 publications

Light-emitting MXene quantum dots

Light-emitting MXene quantum dots

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease

Density Regulation and Localization of Cell Clusters by Self-Assembled Femtosecond-Laser-Fabricated Micropillar Arrays

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