Recent advances in near-infrared light-responsive nanocarriers for cancer therapy

Saneja, Ankit; Kumar, Robin; Arora, Divya; Kumar, Sandeep; Panda, Amulya K.; Jaglan, Sundeep

doi:10.1016/j.drudis.2018.02.005

Cited by 90 publications

(51 citation statements)

References 80 publications

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“…Synergistic phototherapies can be further combined with chemotherapy. Although chemotherapy is widely used in clinics for cancer treatment, its therapeutic effects have been severely hindered by the inherent limitations of chemotherapeutic drugs (e.g., high systemic toxicity and low targeting ability) . Furthermore, in most cases, tumor resistance to chemotherapeutic drugs occurs almost universally during chemotherapy, together with serious neoplasm metastasis and proliferation .…”

Section: Bodipy Nano‐photosensitizers For Combined Pdt and Pttmentioning

confidence: 99%

“…Although chemotherapy is widely used in clinics for cancer treatment, its therapeutic effects have been severely hindered by the inherent limitations of chemotherapeutic drugs (e.g., high systemic toxicity and low targeting ability). [36,[99][100][101] Furthermore, in most cases, tumor resistance to chemotherapeutic drugs occurs almost universally during chemotherapy, together with serious neoplasm metastasis and proliferation. [102][103][104][105][106] an iodine-modified aza-BODIPY PS with a high 1 O 2 quantum yield (0.82 in dichloromethane).…”

Section: Halogenated Bodipy-containing Nano-photosensitizersmentioning

confidence: 99%

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Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Sun

Zhao

Fan

et al. 2019

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149

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As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY‐containing nano‐photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano‐photosensitizers demonstrate a promising potential for fighting cancer. This review contains three sections, classifying photodynamic therapy (PDT), photothermal therapy (PTT), and the combination of PDT and PTT based on BODIPY nano‐photosensitizers. It summarizes various BODIPY nano‐photosensitizers, which are prepared via different approaches including molecular precipitation, supramolecular interactions, and polymer encapsulation. In each section, the design strategies and working principles of these BODIPY nano‐photosensitizers are highlighted. In addition, the detailed in vitro and in vivo applications of these recently developed nano‐photosensitizers are discussed together with future challenges in this field, highlighting the potential of these promising nanoagents for new tumor phototherapies.

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Section: Bodipy Nano‐photosensitizers For Combined Pdt and Pttmentioning

confidence: 99%

Section: Halogenated Bodipy-containing Nano-photosensitizersmentioning

confidence: 99%

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Sun

Zhao

Fan

et al. 2019

Small

149

116

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“…17 (ii) Targeted molecule modified nanoparticles for drug or nucleic acid delivery can achieve tumor-specific killing after intravenous injection. Relative to existing mainstream treatments, PTT exhibits the following unique features.…”

Section: Recent Advance Of Nanoparticle-based Pttmentioning

confidence: 99%

“…(i) A near-infrared (NIR) laser with a strong tissue penetrating capability as the light source and a local fixed-point implementation is suitable for solid tumors, particularly for treating superficial tumors without systematic side effects. 17 (ii) Targeted molecule modified nanoparticles for drug or nucleic acid delivery can achieve tumor-specific killing after intravenous injection. 18,19 (iii) Imaging-guided PTT is facilitated by fluorescence imaging, magnetic resonance imaging, CT imaging, or photoacoustic imaging with theranostic nanoparticles.…”

Section: Recent Advance Of Nanoparticle-based Pttmentioning

confidence: 99%

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

Hou

Tao

Pang

et al. 2018

Intl Journal of Cancer

186

123

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Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. The antitumor effects can be enhanced by immune checkpoint blockage therapy. This article reviewed the recent advances of nanoparticle-based PTT and PDT, summarized the studies on nanoparticle-based photothermal and photodynamic immunotherapies in vitro and in vivo, and discussed challenges and future research directions.

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“…As well-known NIR photothermal conversion agents, GO and rGO have been widely investigated due to their strong lightabsorbing capability and encouraging photothermal therapeutic effects in both in vitro and in vivo experiments. [28][29][30][31][32][33][34][35][36][37] Though some progress has been achieved, the development of methods to synthesize GO (rGO)-based therapeutic systems is necessary. In addition, during cancer therapy, suitable targeting of tumor cells is very important because non-specic targeting can lead to destruction of normal cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel cyclodextrin-modified reduced graphene oxide composites by a simple hydrothermal method

Huang

Wang

et al. 2018

RSC Adv.

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Cyclodextrin (b-CD)-functionalized reduced graphene oxide was successfully synthesized by a simple hydrothermal method, followed by conjugating with polyethylene glycol (PEG) and folic acid (FA).Microscopic and spectroscopic techniques were used to characterize the nanocomposites. Photothermal experiments showed that b-CD-functionalized reduced graphene oxide exhibited higher photothermal conversion efficiency in the near infrared region than reduced graphene oxide functionalized with other molecules under the same conditions. Cytotoxicity experiments indicated that rGO@CD@PEG@FA possessed good biocompatibility even at high concentration. When doxorubicin (DOX) was loaded on the rGO@CD@PEG@FA nanocomposite, it showed the stimulative effect of heat, pH response, and sustained drug release. Cytotoxicity experiments also confirmed the targeted effect and high efficiency of the combined therapy. The findings of the present study provide an ideal drug delivery system for malignant cancer therapy due to the advanced synergistic chemo-photothermal targeted therapy and good drug release properties.

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Recent advances in near-infrared light-responsive nanocarriers for cancer therapy

Cited by 90 publications

References 80 publications

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

Synthesis of novel cyclodextrin-modified reduced graphene oxide composites by a simple hydrothermal method

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