Recent Advances in Nanoparticle-Mediated Co-Delivery System: A Promising Strategy in Medical and Agricultural Field

Abstract

Drug and gene delivery systems mediated by nanoparticles have been widely studied for life science in the past decade. The application of nano-delivery systems can dramatically improve the stability and delivery efficiency of carried ingredients, overcoming the defects of administration routes in cancer therapy, and possibly maintaining the sustainability of agricultural systems. However, delivery of a drug or gene alone sometimes cannot achieve a satisfactory effect. The nanoparticle-mediated co-delivery system can load multiple drugs and genes simultaneously, and improve the effectiveness of each component, thus amplifying efficacy and exhibiting synergistic effects in cancer therapy and pest management. The co-delivery system has been widely reported in the medical field, and studies on its application in the agricultural field have recently begun to emerge. In this progress report, we summarize recent progress in the preparation and application of drug and gene co-delivery systems and discuss the remaining challenges and future perspectives in the design and fabrication.

RNAi-chitosan biopesticides for managing forest insect pests: an outlook

“…Recently, RCNPs were used in the field, and the result demonstrated their compact size, cationic charge, effective loading, resistance to degradation, effective cellular uptake, stability, and adhesion to leaf surfaces (Petek et al, 2020;Kolge et al, 2021Kolge et al, , 2023. Few RNAi-based insecticides have so far been licensed and will soon be available on the market (Li et al, 2023;Pallis et al, 2023).…”

A Combinatorial Nanobased Spray-Induced Gene Silencing Technique for Crop Protection and Improvement

“…To construct such a nanopesticide, the insoluble active ingredient is fused with the inorganic coating of nanoparticles or conjugated with the polymers. Likewise, silica-made nanoparticles are generally used for making nanofertilizers and pesticides . Chaud and his team have demonstrated cluster-based metallic nanomaterials comprising thiophanate methyl, encapsulation containing trichlorfon and acetochlor, and micelle cum nanoemulsion-based particles filled with pyrethrin and citronella, types of nanopesticides .…”

Nano-Agrochemicals as Substitutes for Pesticides: Prospects and Risks

“…Furthermore, it enhances the activity of substances by facilitating improved interactions with various harmful pests [ 123 ]. It shows a 31% increase in efficacy against target organisms and a 43% decrease in toxicity towards non-target organisms [ 183 ]. NCs have the potential to enhance the efficacy of pesticides through improvements in permeability, solubility, stability, and controlled release mechanisms [ 2 ].…”