Recent Advances in Nanogenerator‐Driven Self‐Powered Implantable Biomedical Devices

Mahmud, Arafat; Huda, Nazmul; Farjana, Shahjadi Hisan; Asadnia, Mohsen; Lang, Candace

doi:10.1002/aenm.201701210

Cited by 168 publications

(56 citation statements)

References 97 publications

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“…[ 30 ] Typically, the implantable devices are encapsulated with various soft materials to prevent short‐circuit, while avoiding mechanical damage or immune rejection caused by the devices. [ 31,32 ] Therefore, we propose a remote‐controlled implantable gas therapy system to integrate NO donor and the encapsulated materials into a device for improved stability of NO donor and increased controllability of NO release.…”

Section: Methodsmentioning

confidence: 99%

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Peng

et al. 2020

Advanced Materials

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Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)‐release device is developed to achieve long‐term, long‐distance, remote‐controllable gas therapy for cancer. The device consists of a wirelessly powered light‐emitting diode (wLED) and S‐nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO‐release wLED (NO‐wLED). It is found that NO release from the NO‐wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 × 10−6 m min−1, which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO‐wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO‐wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long‐wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote‐controlled by wireless charging.

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Section: Methodsmentioning

confidence: 99%

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Peng

et al. 2020

Advanced Materials

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“…However, the signals transmitted through human skin are usually weak and susceptible to body movements. In order to eliminate the interference of human activities and monitor these signals with higher fidelity and accuracy, implantable sensors have been invented to meet this demand . Compared with wearable sensors, the obtained signals by implantable sensors convey more detailed medical information.…”

Section: Self‐powered Sensors For Medical Signals Detectionmentioning

confidence: 99%

The recent advances in self‐powered medical information sensors

Zhao

Meng

et al. 2019

InfoMat

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Monitoring various medical information distributed throughout the body is of great importance in early clinic diagnosis and treatment of disease. To discover abnormal medical signals and find their causes in good time, the human body should be monitored continuously and accurately. To meet the requirements, various battery-less and self-powered information acquisition techniques are invented. In this review, the recent advances in self-powered medical information sensors (SMIS) with different functions, structure design, and electric performance are summarized and discussed. The SMIS mainly involves triboelectric nanogenerator (TENG), piezoelectric nanogenerator (PENG), pyroelectric nanogenerator (PyNG)/ thermoelectric generator (TEG) and solar cell. Additionally, this review also analyzed the remaining challenges and prospected the development direction of SMIS in future. K E Y W O R D Smedical information, piezoelectric nanogenerator, self-powered sensor, solar cells, thermoelectric generators, triboelectric nanogenerator Note: PE/TENG represents hybrid PENG and TENG. Py/PE/TENG represents hybrid PyNG, PENG, and TENG. Aorta porcine 79

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“…Recent fast advances in electronic materials, fabrication processes, and device structures have been transforming traditional wafer electronics to be soft, stretchy, and reconfigurable. In particular, owing to their superior mechanical characteristics, i.e., soft, bendable, stretchable, and twistable, stretchable electronics hold promise in health monitors, medical implants, artificial skins, human–machine interfaces, wearable internet of things, etc.…”

Section: Introductionmentioning

confidence: 99%

Rubbery Electronics Fully Made of Stretchable Elastomeric Electronic Materials

2019

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processes, and device structures have been transforming traditional wafer electronics to be soft, stretchy, and reconfigurable. In particular, owing to their superior mechanical characteristics, i.e., soft, bendable, stretchable, and twistable, stretchable electronics hold promise in health monitors, [1] medical implants, [2][3][4][5][6][7][8][9][10] artificial skins, [5,6,[11][12][13][14][15] human-machine interfaces, [11,[16][17][18][19][20] wearable internet of things, [21][22][23][24] etc.As the core and fundamental building block of active electronics, transistors constructed from semiconductors, conductors, and dielectrics are key to enabling electrical functionalities such as switching and amplification. To make transistors stretchable, either the associated electronic materials need to be stretchable or special mechanical structures and layouts need to be included in the transistor design. There are many studies reporting stretchable conductors, as reviewed in the following, while many readily available dielectric materials are stretchy. These have significantly offered many possible options in the device design space. To date, the dominant semiconductors employed for stretchable electronics are either conventional or emerging semiconductors. However, these materials, either in the format of inorganics (such as Si, GaAs, oxides) or organics (such as poly(3-hexylthiophene-2,5-diyl) or P3HT, pentacene), are mechanically nonstretchable. [20,21] Existing strategies to make these nonstretchable semiconductors stretchable mainly involve creating special mechanical structures or architectures with these materials, such as out-of-plane wrinkles, [25,26] in-plane serpentines, [27,28] rigid islands with deformable interconnects, [29][30][31] and kirigami architectures, [32][33][34] to eliminate mechanical strain while they are stretched. However, these approaches require sophisticated structural designs, complicated manufacturing processes, or consume a large area due to stretchable interconnection, all of which pose substantial challenges in high-density integration, packaging, associated high cost, and mass production.Constructing devices all from intrinsically stretchable elastomeric electronic materials offers another interesting yet promising route toward stretchable transistors and electronics. These types of electronics, namely rubbery electronics, neatly avoid the aforementioned challenges since they do not require structural engineering for device fabrication and the manufacturing processes can be adopted into conventional fabrication processes. [29,35] In addition, rubbery electronics offer better cost Stretchable electronics outperform existing rigid and bulky electronics and benefit a wide range of species, including humans, machines, and robots, whose activities are associated with large mechanical deformation and strain. Due to the nonstretchable nature of most electronic materials, in particular semiconductors, stretchable electronics are mostly realized through the strategies of architectural engine...

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Recent Advances in Nanogenerator‐Driven Self‐Powered Implantable Biomedical Devices

Cited by 168 publications

References 97 publications

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

The recent advances in self‐powered medical information sensors

Rubbery Electronics Fully Made of Stretchable Elastomeric Electronic Materials

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