Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment

Abstract

By virtue of the unique magnetic properties and other functionalities, multifunctional magnetic nanoparticles (MNPs) are very promising in diagnostic and therapeutic applications. This review summarizes recent developments pertaining to the synthesis of MNPs with focus on the various surface modification strategies such as chemical synthesis, self-assembly, and ligand exchange. Recent applications of MNPs to multimodal imaging including magnetic resonance imaging (MRI)/optical imaging (fluorescent dyes, quantum dots (QDs), near-infrared absorption and up-conversion luminescence, MRI/positron emission tomography (PET), MRI/X-ray computed tomography (CT), and triple modality imaging are discussed. In addition, targeted drug and gene delivery, hyperthermia treatment for cancer, and other biomedical diagnosis rendered possible by MNPs are described.

Advances in Magnetic Nanoparticles for Biomedical Applications

“…Besides their intrinsic nanoscale physical phenomena, their often exhibit exceptional optical, electrical, magnetic, and chemical properties, attracting vast attention in many biotechnological areas, such as magnetic resonance imaging, drug delivery systems, hyperthermia and labeling and separation of cells and proteins, among other biological entities . Different kinds of NPs, such as quantum dots, carbon nanotubes, gold NPs, silica NPs, polymeric NPs, and magnetic NPs (MNPs) have been designed and synthesized.…”

Effect of the Li+ ion on the multimodal emission of a lanthanide doped phosphor

“…[1][2][3][4][5][6] Recent research on these phosphors broadly covers two principle areas, namely bio-imaging and energy harvesting. [1][2][3][4][5][6] Recent research on these phosphors broadly covers two principle areas, namely bio-imaging and energy harvesting.…”

Fabrication and Characterisation of Novel Natural <i>Lycopodium clavatum</i> Sporopollenin Microcapsules Loaded <i>In-Situ</i> with Nano-Magnetic Humic Acid-Metal Complexes

“…The paramagnetic iron oxide magnetite nanoparticles have attracted intriguing attentions in several environmental and biomedical applications owing to their biocompatibility [14]- [21]. They were usually surface modified with different functional groups in order to enhance their dispersion stability and affinity to different target species [14] [15] [16].…”

“…They were usually surface modified with different functional groups in order to enhance their dispersion stability and affinity to different target species [14] [15] [16]. Immobilisation of biocompatible materials to these magnetic nanoparticles has provided a swift and safe separation of different biological molecules by utilising an external magnetic field [17] [18] [19].…”