Recent advances in microparticle continuous separation

Kersaudy-Kerhoas, Maïwenn; Dhariwal, R. S.; Desmulliez, Marc Phillipe Yves

doi:10.1049/iet-nbt:20070025

Cited by 96 publications

(84 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This type of separation would rely on nondeterministic approaches (biased diffusion). Though this idea had been described and theories were available for gaseous targets and examples based on movement through lipid membranes [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], very little work was published on the application of the mechanism for separation of components of liquid solutions. In addition, the NRL study would evaluate the impact of combining chemical functionalities with biased diffusion in an attempt to further enhance the process.…”

Section: Introductionmentioning

confidence: 99%

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

Malanoski¹,

White²,

Erickson³

2012

View full text Add to dashboard Cite

Standard Form 298 (Rev. 8-98)Prescribed by ANSI Std. Z39.18Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) SPONSOR / MONITOR'S ACRONYM(S) 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) SPONSOR / MONITOR'S REPORT NUMBER(S) NRLThis report summarizes the results of studies conducted to evaluate the potential utility of separation techniques based on Brownian motion. Two generations of ratchet devices and four different chemical functionalities were evaluated. The devices were used to alter concentration profiles for polystyrene nanoparticles in aqueous solutions. Key paramaters such as feature size, flow rate, and particle concentration were considered. The study demonstrated that nondeterministic separation has potential for application to continuous separation of nanoparticle materials. In addition, it demonstrated that chemical surface functionalities can be used to significantly alter the performance of the devices.

show abstract

Section: Introductionmentioning

confidence: 99%

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

Malanoski¹,

White²,

Erickson³

2012

View full text Add to dashboard Cite

show abstract

“…This approach is however difficult to achieve in microsystem devices where viscous forces usually dominate inertial effects. This challenge has led to an interest in adopting new strategies for the separation of micron size particles [2]. These separation methods can be either classified under mechanical sorting e.g.…”

Section: Introductionmentioning

confidence: 99%

Progress towards the design and numerical analysis of a 3D microchannel biochip separator

Xue¹,

Marson²,

Patel³

et al. 2011

Numer Methods Biomed Eng

View full text Add to dashboard Cite

This paper reports the design and numerical analysis of a three‐dimensional biochip plasma blood separator using computational fluid dynamics techniques. Based on the initial configuration of a two‐dimensional (2D) separator, five three‐dimensional (3D) microchannel biochip designs are categorically developed through axial and plenary symmetrical expansions. These include the geometric variations of three types of the branch side channels (circular, rectangular, disc) and two types of the main channel (solid and concentric). Ignoring the initial transient behaviour and assuming that steady‐state flow has been established, the behaviour of the blood fluid in the devices is algebraically analysed and numerically modelled. The roles of the relevant microchannel mechanisms, i.e. bifurcation, constriction and bending channel, on promoting the separation process are analysed based on modelling results. The differences among the different 3D implementations are compared and discussed. The advantages of 3D over 2D separator in increasing separation volume and effectively depleting cell‐free layer fluid from the whole cross section circumference are addressed and illustrated. Copyright © 2011 John Wiley & Sons, Ltd.

show abstract

“…The separation of polymer microparticles is of particular interest [10]. Such particles are commonly used as solid supports in biomedical and chemical applications [11,12].…”

Section: Introductionmentioning

confidence: 99%

On-chip diamagnetic repulsion in continuous flow

Tarn

Hirota

Iles

et al. 2009

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

We explore the potential of a microfluidic continuous flow particle separation system based on the repulsion of diamagnetic materials from a high magnetic field. Diamagnetic polystyrene particles in paramagnetic manganese (II) chloride solution were pumped into a microfluidic chamber and their deflection behaviour in a high magnetic field applied by a superconducting magnet was investigated. Two particle sizes (5 and 10 µm) were examined in two concentrations of MnCl 2 (6 and 10%). The larger particles were repelled to a greater extent than the smaller ones, and the effect was greatly enhanced when the particles were suspended in a higher concentration of MnCl 2 . These findings indicate that the system could be viable for the separation of materials of differing size and/or diamagnetic susceptibility, and as such could be suitable for the separation and sorting of small biological species for subsequent studies.

show abstract

Recent advances in microparticle continuous separation

Cited by 96 publications

References 45 publications

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

Progress towards the design and numerical analysis of a 3D microchannel biochip separator

On-chip diamagnetic repulsion in continuous flow

Contact Info

Product

Resources

About