Recent advances in microfluidics-based paper analytical devices (µPADs) for biochemical sensors: From fabrication to detection techniques

Kulkarni, Madhusudan B.; Ayachit, N. H.; Aminabhavi, Tejraj M.; Pogue, Brian W.

doi:10.1016/j.bej.2023.109027

Cited by 15 publications

(5 citation statements)

References 177 publications

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“…21,22 Paper is used as a microfluidic substrate for the identification of various biomolecules and the examination of liquids. 23–27 In order to restrict the amount of fluids that are dispersed on the paper substrate, hydrophobically patterned paper is utilised in the process of conducting targeted chemical analysis. 28–30 Furthermore, the amount of sample needed for this analysis is smaller in comparison to conventional chemical analysis.…”

Section: Introductionmentioning

confidence: 99%

On paper characterisation of droplet and evaporation study using impedance spectroscopy

Siva Prakasam,

Basu,

Chaudhury

et al. 2024

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

On paper characterisation of droplet and evaporation study using impedance spectroscopy

Siva Prakasam,

Basu,

Chaudhury

et al. 2024

Anal. Methods

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“…The most widespread biopolymers, cellulosic materials, are successfully commercialized as microfluidic, paper-based devices. Fluids are transported through the device by capillary actions, and the resulting LoCs address a wide range of applications [ 27 , 28 ]. However, the transportation mode restricts the potential applications to biomarker detection or DNA extraction and does not allow for cell manipulation [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan as an Alternative to Oil-Based Materials for the Fabrication of Lab-on-a-Chip

Zimmer,

Trombotto,

Laurenceau

et al. 2024

Micromachines

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Given the growing importance of lab-on-a-chip in a number of fields, such as medical diagnosis or environmental analysis, the fact that the current fabrication process relies mainly on oil-based polymers raises an ecological concern. As an eco-responsible alternative, we presented, in this article, a manufacturing process for microfluidic devices from chitosan, a bio-sourced, biodegradable, and biocompatible polysaccharide. From chitosan powder, we produced thick and rigid films. To prevent their dissolution and reduce their swelling when in contact with aqueous solutions, we investigated a film neutralization step and characterized the mechanical and physical properties of the resulting films. On these neutralized chitosan films, we compared two micropatterning methods, i.e., hot embossing and mechanical micro-drilling, based on the resolution of microchannels from 100 µm to 1000 µm wide. Then, chitosan films with micro-drilled channels were bonded using a biocompatible dry photoresist on a glass slide or another neutralized chitosan film. Thanks to this protocol, the first functional chitosan microfluidic devices were prepared. While some steps of the fabrication process remain to be improved, these preliminary results pave the way toward a sustainable fabrication of lab-on-a-chip.

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“…(2) The device should have good biocompatibility to avoid skin irritation. (3) The device should be lightweight and comfortable to ensure comfort [12][13][14][15][16][17]. Recent research has shown that health monitoring devices have achieved high performance by integrating high-precision wearable sensors and computers [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Wearable Near-Sensor and In-Sensor Intelligent Perception Systems

Liu,

Wang,

Liu

et al. 2024

Sensors

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As the Internet of Things (IoT) becomes more widespread, wearable smart systems will begin to be used in a variety of applications in people’s daily lives, not only requiring the devices to have excellent flexibility and biocompatibility, but also taking into account redundant data and communication delays due to the use of a large number of sensors. Fortunately, the emerging paradigms of near-sensor and in-sensor computing, together with the proposal of flexible neuromorphic devices, provides a viable solution for the application of intelligent low-power wearable devices. Therefore, wearable smart systems based on new computing paradigms are of great research value. This review discusses the research status of a flexible five-sense sensing system based on near-sensor and in-sensor architectures, considering material design, structural design and circuit design. Furthermore, we summarize challenging problems that need to be solved and provide an outlook on the potential applications of intelligent wearable devices.

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Recent advances in microfluidics-based paper analytical devices (µPADs) for biochemical sensors: From fabrication to detection techniques

Cited by 15 publications

References 177 publications

On paper characterisation of droplet and evaporation study using impedance spectroscopy

On paper characterisation of droplet and evaporation study using impedance spectroscopy

Chitosan as an Alternative to Oil-Based Materials for the Fabrication of Lab-on-a-Chip

Recent Progress in Wearable Near-Sensor and In-Sensor Intelligent Perception Systems

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